2019 |
J.L, Ayuso-Mateos. Suicide prevention: towards an evidencebased policy Artículo de revista Epidemiology and Psychiatric Sciences, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{J.L2019b, title = {Suicide prevention: towards an evidencebased policy}, author = {J.L, Ayuso-Mateos.}, url = {https://www.cambridge.org/core/journals/epidemiology-and-psychiatric-sciences/article/suicide-prevention-towards-an-evidencebased-policy/3847DF8E7A20EAFD5A6BF7505B609AEC}, doi = {/10.1017/S204579601900012X}, year = {2019}, date = {2019-03-15}, journal = {Epidemiology and Psychiatric Sciences}, abstract = {Suicide prevention and adequate management of those with suicidal behaviour should be one of the major drivers in designing clinical services and guiding mental health policy decisions at all levels. In order for these decisions and this guidance to be effective, they need to be based on relevant and robust evidence covering both the magnitude of the problem at the local level where the decisions aim to have an impact, and on the effect that potential interventions may have on suicide and suicidal behaviour at the clinical and the population level. This issue of Epidemiology and Psychiatric Sciences includes two valuable contributions to the theoretical framework that needs to be used for an evidence-based policy on this area...}, keywords = {}, pubstate = {published}, tppubtype = {article} } Suicide prevention and adequate management of those with suicidal behaviour should be one of the major drivers in designing clinical services and guiding mental health policy decisions at all levels. In order for these decisions and this guidance to be effective, they need to be based on relevant and robust evidence covering both the magnitude of the problem at the local level where the decisions aim to have an impact, and on the effect that potential interventions may have on suicide and suicidal behaviour at the clinical and the population level. This issue of Epidemiology and Psychiatric Sciences includes two valuable contributions to the theoretical framework that needs to be used for an evidence-based policy on this area... |
García Robles, R; JL., Ayuso-Mateos CIE-11 and the depathologisation of the transgender condition. Artículo de revista Revista de psiquiatria y salud mental, 2019. @article{Robles2019, title = {CIE-11 and the depathologisation of the transgender condition.}, author = {Garc\'{i}a Robles, R and Ayuso-Mateos JL.}, url = {https://www.sciencedirect.com/science/article/pii/S1888989119300035?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30846280}, doi = {10.1016/j.rpsm.2019.01.002}, year = {2019}, date = {2019-03-04}, journal = {Revista de psiquiatria y salud mental}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
de la Torre-Luque, A; de la Fuente, J; Prina, M; Sanchez-Niubo, A; Haro, J M; Ayuso-Mateos, J L Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors Artículo de revista J Affect Disord, 246 , pp. 329–337, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30594876b, title = {Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors}, author = {A de la Torre-Luque and J de la Fuente and M Prina and A Sanchez-Niubo and J M Haro and J L Ayuso-Mateos}, doi = {10.1016/j.jad.2018.12.122}, year = {2019}, date = {2019-03-01}, journal = {J Affect Disord}, volume = {246}, pages = {329--337}, abstract = {This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthy-ageing outcomes later in life. The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription.}, keywords = {}, pubstate = {published}, tppubtype = {article} } This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthy-ageing outcomes later in life. The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription. |
Alem, A; Ayuso-Mateos, J L; Chisholm, D; Evans-Lacko, S; Gureje, O; Hanlon, C; Jordans, M; Kigozi, F; Lund, C; Petersen, I; Semrau, M; Shidhaye, R; Votruba, N; Thornicroft, G Emerging mental health systems in low- and middle-income countries: Recommendations from the EMERALD project Artículo de revista BJPsych Open, 2019. BibTeX | Etiquetas: @article{Alem2019b, title = {Emerging mental health systems in low- and middle-income countries: Recommendations from the EMERALD project}, author = {A Alem and J L Ayuso-Mateos and D Chisholm and S Evans-Lacko and O Gureje and C Hanlon and M Jordans and F Kigozi and C Lund and I Petersen and M Semrau and R Shidhaye and N Votruba and G Thornicroft}, year = {2019}, date = {2019-03-01}, journal = {BJPsych Open}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Evans-Lacko, S; Hanlon, C; Alem, A; Ayuso-Mateos, JL ; Chisholm, D; Gureje, O; Jordans, M; Kigozi, F; Lempp, H; Lund, C; Petersen, I; Shidhaye, R; Thornicroft, G; Semrau, M BJPsych Open, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{Evans-Lacko2019, title = {Evaluation of capacity-building strategies for mental health system strengthening in low- and middle-income countries for service users and carers,policymakers and planners, and researchers}, author = {Evans-Lacko, S and Hanlon, C and Alem, A and Ayuso-Mateos, JL and Chisholm, D and Gureje, O and Jordans, M and Kigozi, F and Lempp, H and Lund, C and Petersen, I and Shidhaye, R and Thornicroft, G and Semrau, M.}, editor = {Cambridge University Press}, url = {http://sro.sussex.ac.uk/id/eprint/82256}, year = {2019}, date = {2019-02-25}, journal = {BJPsych Open}, abstract = {Background Strengthening of mental health systems in low- and middle-income countries (LMICs) requires the involvement of appropriately skilled and committed individuals from a range of stakeholder groups. Currently, few evidence-based capacity building activities and materials are available to enable and sustain comprehensive improvements. Aims Within the Emerald project, the goal of this study was to evaluate capacity-building activities for three target groups: (i) mental health service users and carers; (ii) policy-makers and planners; and (iii) mental health researchers. Method We developed and tailored three short courses (between 1 and 5 days). We then implemented and evaluated these short courses on twenty-four different occasions. We assessed satisfaction among 527 course participants as well as pre-post changes in knowledge in six LMICs (Ethiopia, India, Nepal, Nigeria, South Africa, Uganda). Changes in research capacity of partner Emerald institutions was also assessed through monitoring of academic outputs of participating researchers and students and via anonymous surveys. Results Short courses were associated with high levels of satisfaction and led to improvements in knowledge across target groups. In relation to institutional capacity building, all partner institutions reported improvements in research capacity for most aspects of mental health system strengthening and global mental health, and many of these positive changes were attributed to the Emerald programme. In terms of outputs, eight PhD students submitted a total of 10 papers relating to their PhD work (range 0-4) and were involved in 14 grant applications, of which 43% were successful. Conclusions The Emerald project has shown that building capacity of key stakeholders in mental health system strengthening is possible. However, the starting point and appropriate strategies for this may vary across different countries, depending on the local context, needs and resources.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background Strengthening of mental health systems in low- and middle-income countries (LMICs) requires the involvement of appropriately skilled and committed individuals from a range of stakeholder groups. Currently, few evidence-based capacity building activities and materials are available to enable and sustain comprehensive improvements. Aims Within the Emerald project, the goal of this study was to evaluate capacity-building activities for three target groups: (i) mental health service users and carers; (ii) policy-makers and planners; and (iii) mental health researchers. Method We developed and tailored three short courses (between 1 and 5 days). We then implemented and evaluated these short courses on twenty-four different occasions. We assessed satisfaction among 527 course participants as well as pre-post changes in knowledge in six LMICs (Ethiopia, India, Nepal, Nigeria, South Africa, Uganda). Changes in research capacity of partner Emerald institutions was also assessed through monitoring of academic outputs of participating researchers and students and via anonymous surveys. Results Short courses were associated with high levels of satisfaction and led to improvements in knowledge across target groups. In relation to institutional capacity building, all partner institutions reported improvements in research capacity for most aspects of mental health system strengthening and global mental health, and many of these positive changes were attributed to the Emerald programme. In terms of outputs, eight PhD students submitted a total of 10 papers relating to their PhD work (range 0-4) and were involved in 14 grant applications, of which 43% were successful. Conclusions The Emerald project has shown that building capacity of key stakeholders in mental health system strengthening is possible. However, the starting point and appropriate strategies for this may vary across different countries, depending on the local context, needs and resources. |
E, Lara; N, Martín-María; AK, Forsman; J, Cresswell-Smith; V, Donisi; M, Ådnanes; J, Kaasbøll; L, Melby; J, Nordmyr; L, Nyholm; L, Rabbi; F, Amaddeo; M, Miret Understanding the Multi-Dimensional Mental Well-Being in Late Life: Evidence from the Perspective of the Oldest Old Population. Artículo de revista J Happiness Stud, 2019, ISSN: 1389-4978. Resumen | Enlaces | BibTeX | Etiquetas: @article{E2019b, title = {Understanding the Multi-Dimensional Mental Well-Being in Late Life: Evidence from the Perspective of the Oldest Old Population. }, author = {Lara E and Mart\'{i}n-Mar\'{i}a N and Forsman AK and Cresswell-Smith J and Donisi V and r{A}dnanes M and Kaasb\oll J and Melby L and Nordmyr J and Nyholm L and Rabbi L and Amaddeo F and Miret M}, url = {https://link.springer.com/article/10.1007/s10902-019-00090-1}, doi = {10.1007/s10902-019-00090-1}, issn = {1389-4978}, year = {2019}, date = {2019-02-23}, journal = {J Happiness Stud}, abstract = {The promotion, maintenance, and improvement of well-being among the oldest old population is becoming a great public health concern. This study aimed to explore the experiences of individuals aged 80 plus regarding their mental well-being (MWB) and its contributing factors in four European countries. A qualitative approach was followed, with twenty-three focus groups. One hundred and seventeen respondents were recruited from senior community centers, adult day care centers, and nursing homes. Data was assessed using qualitative content analysis. Participants’ perspectives on MWB were collated along four dimensions: functional, social, personal and environmental. Staying healthy and maintaining independence, having close relationships with others, and insightful experiences with friends positively contributed to MWB. Additionally, engagement in fruitful or inspiring activities contributed to enhance personal development, which, in turn, had beneficial effects on MWB. Having a positive outlook was also found to be associated with MWB. Results reinforce the dynamic and multidimensional nature state of MWB, as well as highlighting the significance of psychosocial factors. Developing and implementing policy actions including a focus on the social and physical environment as well as strengthening personal capabilities and self-esteem, can foster MWB among the oldest old population.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The promotion, maintenance, and improvement of well-being among the oldest old population is becoming a great public health concern. This study aimed to explore the experiences of individuals aged 80 plus regarding their mental well-being (MWB) and its contributing factors in four European countries. A qualitative approach was followed, with twenty-three focus groups. One hundred and seventeen respondents were recruited from senior community centers, adult day care centers, and nursing homes. Data was assessed using qualitative content analysis. Participants’ perspectives on MWB were collated along four dimensions: functional, social, personal and environmental. Staying healthy and maintaining independence, having close relationships with others, and insightful experiences with friends positively contributed to MWB. Additionally, engagement in fruitful or inspiring activities contributed to enhance personal development, which, in turn, had beneficial effects on MWB. Having a positive outlook was also found to be associated with MWB. Results reinforce the dynamic and multidimensional nature state of MWB, as well as highlighting the significance of psychosocial factors. Developing and implementing policy actions including a focus on the social and physical environment as well as strengthening personal capabilities and self-esteem, can foster MWB among the oldest old population. |
Rugulies, R; Ando, E; Ayuso-Mateos, J L; Bonafede, M; Cabello, M; Tecco, Di C; Dragano, N; Durand-Moreau, Q; Eguchi, H; Gao, J; Garde, A H; Iavicoli, S; Ivanov, I D; Leppink, N; Madsen, I E H; Pega, F; Prüss-Üstün, A M; Rondinone, B M; Sørensen, K; Tsuno, K; YUjita, ; Zadow, A Environ Int, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{Rugulies2019, title = {WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on depression.}, author = {R Rugulies and E Ando and J L Ayuso-Mateos and M Bonafede and M Cabello and C Di Tecco and N Dragano and Q Durand-Moreau and H Eguchi and J Gao and A H Garde and S Iavicoli and I D Ivanov and N Leppink and I E H Madsen and F Pega and A M Pr\"{u}ss-\"{U}st\"{u}n and B M Rondinone and K S\orensen and K Tsuno and YUjita and A Zadow}, url = {https://www.sciencedirect.com/science/article/pii/S016041201732175X?via%3Dihub}, doi = {10.1016/j.envint.2018.11.011}, year = {2019}, date = {2019-02-05}, journal = {Environ Int}, abstract = {BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from depression attributable to exposure to long working hours, to inform the development of the WHO/ILO joint methodology. OBJECTIVES: We aim to systematically review studies on occupational exposure to long working hours (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of long working hours on depression (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework, conducting both systematic reviews in tandem and in a harmonized way. DATA SOURCES: Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Medline, EMBASE, Web of Science, CISDOC and PsycINFO. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand search reference list of previous systematic reviews and included study records; and consult additional experts. STUDY ELIGIBILITY AND CRITERIA: We will include working-age (≥15 years) participants in the formal and informal economy in any WHO and/or ILO Member State, but exclude child workers (<15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative prevalence studies of relevant levels of occupational exposure to long working hours (i.e. 35-40, 41-48, 49-54 and ≥55 h/week) stratified by country, sex, age and industrial sector or occupation, in the years 2005-2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the relative effect of relevant level(s) of long working hours on the incidence of or mortality due to depression, compared with the theoretical minimum risk exposure level (i.e. 35-40 h/week). STUDY APPRAISAL AND SYNTHESIS METHODS: At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from depression attributable to exposure to long working hours, to inform the development of the WHO/ILO joint methodology. OBJECTIVES: We aim to systematically review studies on occupational exposure to long working hours (Systematic Review 1) and systematically review and meta-analyse estimates of the effect of long working hours on depression (Systematic Review 2), applying the Navigation Guide systematic review methodology as an organizing framework, conducting both systematic reviews in tandem and in a harmonized way. DATA SOURCES: Separately for Systematic Reviews 1 and 2, we will search electronic academic databases for potentially relevant records from published and unpublished studies, including Medline, EMBASE, Web of Science, CISDOC and PsycINFO. We will also search electronic grey literature databases, Internet search engines and organizational websites; hand search reference list of previous systematic reviews and included study records; and consult additional experts. STUDY ELIGIBILITY AND CRITERIA: We will include working-age (≥15 years) participants in the formal and informal economy in any WHO and/or ILO Member State, but exclude child workers (<15 years) and unpaid domestic workers. For Systematic Review 1, we will include quantitative prevalence studies of relevant levels of occupational exposure to long working hours (i.e. 35-40, 41-48, 49-54 and ≥55 h/week) stratified by country, sex, age and industrial sector or occupation, in the years 2005-2018. For Systematic Review 2, we will include randomized controlled trials, cohort studies, case-control studies and other non-randomized intervention studies with an estimate of the relative effect of relevant level(s) of long working hours on the incidence of or mortality due to depression, compared with the theoretical minimum risk exposure level (i.e. 35-40 h/week). STUDY APPRAISAL AND SYNTHESIS METHODS: At least two review authors will independently screen titles and abstracts against the eligibility criteria at a first stage and full texts of potentially eligible records at a second stage, followed by extraction of data from qualifying studies. At least two review authors will assess risk of bias and the quality of evidence, using the most suited tools currently available. For Systematic Review 2, if feasible, we will combine relative risks using meta-analysis. We will report results using the guidelines for accurate and transparent health estimates reporting (GATHER) for Systematic Review 1 and the preferred reporting items for systematic reviews and meta-analyses guidelines (PRISMA) for Systematic Review 2. |
Reed, G M; First, M B; Kogan, C S; Hyman, S E; Gureje, O; Gaebel, W; Maj, M; Stein, D J; Maercker, A; Tyrer, P; Claudino, A; Garralda, E; Salvador-Carulla, L; Ray, R; Saunders, J B; Dua, T; Poznyak, V; Medina-Mora, M E; Pike, K M; Ayuso-Mateos, J L; Kanba, S; Keeley, J W; Khoury, B; Krasnov, V N; Kulygina, M; Lovell, A M; Mari, J J; Maruta, T; Matsumoto, C; Rebello, T J; Roberts, M C; Robles, R; Sharan, P; Zhao, M; Jablensky, A; Udomratn, P; Rahimi-Movaghar, A; Rydelius, P A; Bährer-Kohler, S; Watts, A D; Saxena, S Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders Artículo de revista World Psychiatry, 18 (1), pp. 3-19, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{Saxena.2019, title = {Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders}, author = {G M Reed and M B First and C S Kogan and S E Hyman and O Gureje and W Gaebel and M Maj and D J Stein and A Maercker and P Tyrer and A Claudino and E Garralda and L Salvador-Carulla and R Ray and J B Saunders and T Dua and V Poznyak and M E Medina-Mora and K M Pike and J L Ayuso-Mateos and S Kanba and J W Keeley and B Khoury and V N Krasnov and M Kulygina and A M. Lovell and J J Mari and T Maruta and C Matsumoto and T J Rebello and M C Roberts and R Robles and P Sharan and M Zhao and A Jablensky and P Udomratn and A Rahimi-Movaghar and P A Rydelius and S B\"{a}hrer-Kohler and A D. Watts and S Saxena}, doi = {10.1002/wps.20611}, year = {2019}, date = {2019-02-01}, journal = {World Psychiatry}, volume = {18}, number = {1}, pages = {3-19}, abstract = {Following approval of the ICD-11 by the World Health Assembly in May 2019, World Health Organization (WHO) member states will transition from the ICD-10 to the ICD-11, with reporting of health statistics based on the new system to begin on January 1, 2022. The WHO Department of Mental Health and Substance Abuse will publish Clinical Descriptions and Diagnostic Guidelines (CDDG) for ICD-11 Mental, Behavioural and Neurodevelopmental Disorders following ICD-11’s approval. Te development of the ICD-11 CDDG over the past decade, based on the principles of clinical utility and global applicability, has been the most broadly international, multilingual, multidisciplinary and participative revision process ever implemented for a classifcation of mental disorders. Innovations in the ICD-11 include the provision of consistent and systematically characterized information, the adoption of a lifespan approach, and culture-related guidance for each disorder. Dimensional approaches have been incorporated into the classifcation, particularly for personality disorders and primary psychotic disorders, in ways that are consistent with current evidence, are more compatible with recovery-based approaches, eliminate artifcial comorbidity, and more efectively capture changes over time. Here we describe major changes to the structure of the ICD-11 classifcation of mental disorders as compared to the ICD-10, and the development of two new ICD-11 chapters relevant to mental health practice. We illustrate a set of new categories that have been added to the ICD-11 and present the rationale for their inclusion. Finally, we provide a description of the important changes that have been made in each ICD-11 disorder grouping. Tis information is intended to be useful for both clinicians and researchers in orienting themselves to the ICD-11 and in preparing for implementation in their own professional contexts. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Following approval of the ICD-11 by the World Health Assembly in May 2019, World Health Organization (WHO) member states will transition from the ICD-10 to the ICD-11, with reporting of health statistics based on the new system to begin on January 1, 2022. The WHO Department of Mental Health and Substance Abuse will publish Clinical Descriptions and Diagnostic Guidelines (CDDG) for ICD-11 Mental, Behavioural and Neurodevelopmental Disorders following ICD-11’s approval. Te development of the ICD-11 CDDG over the past decade, based on the principles of clinical utility and global applicability, has been the most broadly international, multilingual, multidisciplinary and participative revision process ever implemented for a classifcation of mental disorders. Innovations in the ICD-11 include the provision of consistent and systematically characterized information, the adoption of a lifespan approach, and culture-related guidance for each disorder. Dimensional approaches have been incorporated into the classifcation, particularly for personality disorders and primary psychotic disorders, in ways that are consistent with current evidence, are more compatible with recovery-based approaches, eliminate artifcial comorbidity, and more efectively capture changes over time. Here we describe major changes to the structure of the ICD-11 classifcation of mental disorders as compared to the ICD-10, and the development of two new ICD-11 chapters relevant to mental health practice. We illustrate a set of new categories that have been added to the ICD-11 and present the rationale for their inclusion. Finally, we provide a description of the important changes that have been made in each ICD-11 disorder grouping. Tis information is intended to be useful for both clinicians and researchers in orienting themselves to the ICD-11 and in preparing for implementation in their own professional contexts. |
Gili, M; Castellví, P; Vives, M; de la Torre-Luque, A; Almenara, J; et al. Blasco, M Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies Artículo de revista J Affect Disord. , (245), pp. 152-262, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{Gili2019, title = {Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies}, author = {Gili, M and Castellv\'{i}, P and Vives, M and de la Torre-Luque, A and Almenara, J and Blasco, M et al.}, doi = {10.1016/j.jad.2018.10.115}, year = {2019}, date = {2019-02-01}, journal = {J Affect Disord. }, number = {245}, pages = {152-262}, abstract = {BACKGROUND: Suicide is the second leading cause of death for young people. OBJECTIVE: To assess mental disorders as risk factors for suicidal behaviour among adolescents and young adults including population-based longitudinal studies. METHOD: We conducted a systematic literature review. Bibliographic searches undertaken in five international databases and grey literature sources until January 2017 yielded a total of 26,883 potential papers. 1701 full-text articles were assessed for eligibility of which 1677 were excluded because they did not meet our eligibility criteria. Separate meta-analyses were conducted for each outcome (suicide death and suicide attempts). Odds ratio (OR) and 95% confidence intervals (95%CI) and beta coefficients and standard errors were calculated. RESULTS: 24 studies were finally included involving 25,354 participants (12-26 years). The presence of any mental disorder was associated with higher risk of suicide death (OR = 10.83, 95%CI = 4.69-25.00) and suicide attempt (OR = 3.56; 95%CI 2.24-5.67). When considering suicidal attempt as the outcome, only affective disorders (OR = 1.54; 95%CI = 1.21-1.96) were significant. Finally, the results revealed that psychiatric comorbidity was a primary risk factor for suicide attempts. LIMITATIONS: Data were obtained from studies with heterogeneous diagnostic assessments of mental disorders. Nine case-control studies were included and some data were collected in students, not in general population. CONCLUSIONS: Mental disorders and comorbidity are strong predictors of suicide behaviour in young people. Detection and management of the affective disorders as well as their psychiatric comorbidity could be a crucial strategy to prevent suicidality in this age group.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Suicide is the second leading cause of death for young people. OBJECTIVE: To assess mental disorders as risk factors for suicidal behaviour among adolescents and young adults including population-based longitudinal studies. METHOD: We conducted a systematic literature review. Bibliographic searches undertaken in five international databases and grey literature sources until January 2017 yielded a total of 26,883 potential papers. 1701 full-text articles were assessed for eligibility of which 1677 were excluded because they did not meet our eligibility criteria. Separate meta-analyses were conducted for each outcome (suicide death and suicide attempts). Odds ratio (OR) and 95% confidence intervals (95%CI) and beta coefficients and standard errors were calculated. RESULTS: 24 studies were finally included involving 25,354 participants (12-26 years). The presence of any mental disorder was associated with higher risk of suicide death (OR = 10.83, 95%CI = 4.69-25.00) and suicide attempt (OR = 3.56; 95%CI 2.24-5.67). When considering suicidal attempt as the outcome, only affective disorders (OR = 1.54; 95%CI = 1.21-1.96) were significant. Finally, the results revealed that psychiatric comorbidity was a primary risk factor for suicide attempts. LIMITATIONS: Data were obtained from studies with heterogeneous diagnostic assessments of mental disorders. Nine case-control studies were included and some data were collected in students, not in general population. CONCLUSIONS: Mental disorders and comorbidity are strong predictors of suicide behaviour in young people. Detection and management of the affective disorders as well as their psychiatric comorbidity could be a crucial strategy to prevent suicidality in this age group. |
A, Foscolou ; E, Critselis ; S, Tyrovolas ; C, Chrysohoou ; L S, Sidossis ; N, Naumovski ; A L, Matalas ; L, Rallidis ; E, Polychronopoulos ; J L, Ayuso-Mateos ; J M, Haro ; D, Panagiotakos The Effect of Exclusive Olive Oil Consumption on Successful Aging: A Combined Analysis of the ATTICA and MEDIS Epidemiological Studies Artículo de revista Foods, 8 (1), 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{A2019, title = {The Effect of Exclusive Olive Oil Consumption on Successful Aging: A Combined Analysis of the ATTICA and MEDIS Epidemiological Studies}, author = {A, Foscolou and E, Critselis and S, Tyrovolas and C, Chrysohoou and L S, Sidossis and N, Naumovski and A L, Matalas and L, Rallidis and E, Polychronopoulos and J L, Ayuso-Mateos and J M, Haro and D, Panagiotakos}, doi = {10.3390/foods8010025}, year = {2019}, date = {2019-01-12}, journal = {Foods}, volume = {8}, number = {1}, abstract = {The consumption of dietary fats, which occur naturally in various foods, poses important impacts on health. The aim of this study was to elucidate the association of exclusive use of olive oil for culinary purposes with successful aging in adults aged >50 years old and residing in Greece. Use of olive oil in food preparation and bio-clinical characteristics of the Greek participants enrolled in the ATTICA (n = 1128 adults from Athens metropolitan area) and the MEDiterranean Islands Study (MEDIS) (n = 2221 adults from various Greek islands and Mani) studies, were investigated in relation to successful aging (SA). Participants were divided into the following three categories: (a) no olive oil consumption; (b) combined consumption of olive oil and other dietary fats; and (c) exclusive olive oil consumption. The SA was measured using the previously validated successful aging index (SAI). After adjusting for age, sex, and smoking habits, combined consumption of olive oil and other fats (vs. no olive oil use) was not significantly associated with SAI levels (p = 0.114). However, exclusive olive oil intake (vs. no use of olive oil) was significantly associated with SAI (p = 0.001), particularly among those aged older than 70 years. Therefore, the exclusive consumption of olive oil, as opposed to either combined or no olive oil consumption, beneficially impacts successful aging, particularly among individuals over 70 years of age. Primary public health prevention strategies should seek to encourage the enhanced adoption of such dietary practices in order to promote healthy aging and longevity.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The consumption of dietary fats, which occur naturally in various foods, poses important impacts on health. The aim of this study was to elucidate the association of exclusive use of olive oil for culinary purposes with successful aging in adults aged >50 years old and residing in Greece. Use of olive oil in food preparation and bio-clinical characteristics of the Greek participants enrolled in the ATTICA (n = 1128 adults from Athens metropolitan area) and the MEDiterranean Islands Study (MEDIS) (n = 2221 adults from various Greek islands and Mani) studies, were investigated in relation to successful aging (SA). Participants were divided into the following three categories: (a) no olive oil consumption; (b) combined consumption of olive oil and other dietary fats; and (c) exclusive olive oil consumption. The SA was measured using the previously validated successful aging index (SAI). After adjusting for age, sex, and smoking habits, combined consumption of olive oil and other fats (vs. no olive oil use) was not significantly associated with SAI levels (p = 0.114). However, exclusive olive oil intake (vs. no use of olive oil) was significantly associated with SAI (p = 0.001), particularly among those aged older than 70 years. Therefore, the exclusive consumption of olive oil, as opposed to either combined or no olive oil consumption, beneficially impacts successful aging, particularly among individuals over 70 years of age. Primary public health prevention strategies should seek to encourage the enhanced adoption of such dietary practices in order to promote healthy aging and longevity. |
Salagre, E; Arango, C; Artigas, F; Ayuso-Mateos, J L; Bernardo, M; Castro-Fornieles, J; Bobes, J; Desco, M; Fananás, L; González-Pinto, ; María Haro, J; Leza, J C; Mckenna, J C; Meana, J J; Menchón, J M; Micó, J A; Palomo, T; Pazos, A; Pérez, V; Saiz-Ruiz, J; Sanjuán, J; Tabarés-Seisdedos, R; Crespo-Facorro, B; Casas, M; Vilella, E; Palao, D; Olivares, J M; Rodriguez-Jimenez, R; Vieta, E Diez años de investigación traslacional colaborativa en enfermedades mentales: el CIBERSAM Artículo de revista Revista de Psiquiatría y Salud Mental, 12 (1), pp. 1-8, 2019. Resumen | Enlaces | BibTeX | Etiquetas: @article{Salagre2019, title = {Diez a\~{n}os de investigaci\'{o}n traslacional colaborativa en enfermedades mentales: el CIBERSAM}, author = {Salagre, E and Arango,C and Artigas, F and Ayuso-Mateos, J.L and Bernardo, M and Castro-Fornieles, J and Bobes, J and Desco, M and Fanan\'{a}s, L and Gonz\'{a}lez-Pinto, and Mar\'{i}a Haro, J and Leza, J.C and Mckenna, J.C and Meana, J.J and Mench\'{o}n, J.M and Mic\'{o}, J.A and Palomo, T and Pazos, A and P\'{e}rez, V and Saiz-Ruiz, J and Sanju\'{a}n, J and Tabar\'{e}s-Seisdedos, R and Crespo-Facorro, B and Casas, M and Vilella, E and Palao, D and Olivares, J.M and Rodriguez-Jimenez, R and Vieta, E. }, editor = {Elsevier Doyma}, url = {https://www.sciencedirect.com/science/article/pii/S1888989118300958?via%3Dihub }, doi = {10.1016/j.rpsm.2018.10.001}, year = {2019}, date = {2019-01-01}, journal = {Revista de Psiquiatr\'{i}a y Salud Mental}, volume = {12}, number = {1}, pages = {1-8}, abstract = {Hace 10 anos ˜ que el Centro de Investigaci\'{o}n Biom\'{e}dica en Red de Salud Mental (CIBERSAM) naci\'{o} con el objetivo principal de favorecer la investigaci\'{o}n traslacional colaborativa de excelencia en salud mental. Tambi\'{e}n hace 10 a\~{n}os que se puso en marcha la Revista de Psiquiatr\'{I}a y Salud Mental. Dicha revista ha acompanado al CIBERSAM desde sus inicios y ha publicado m\'{a}s de 100 trabajos de investigadores del CIBERSAM. Por ello, hemos querido publicar este art\'{i}culo que resume la trayectoria del CIBERSAM durante una d\'{e}cada en la Revista de Psiquiatr\'{I}a y Salud Mental. Concebido inicialmente como una red de investigaci\'{o}n colaborativa (Red de Enfermedades Mentales, Trastornos Afectivos y Psic\'{o}ticos [REM-TAP]), el CIBERSAM naci\'{o} formalmente en 2007, y de forma efectiva en 2008, para integrar a los grupos de investigaci\'{o}n b\'{a}sica y cl\'{i}nica en psiquiatr\'{i}a, salud mental y ciencias afines m\'{a}s destacados del pa\'{i}s, como qued\'{o} plasmado en un n\'{u}mero especial que, en 2009, le dedic\'{o} la revista The European Journal of Psychiatry1. El CIBERSAM tiene un car\'{a}cter abierto, competitivo y meritocr\'{a}tico con base en criterios cient\'{i}ficos, lo que lo convierte en una estructura din\'{a}mica, con evaluaci\'{o}n anual y entrada y salida de grupos en funci\'{o}n de su productividad. Aunque algunos grupos presentes en el momento de la creaci\'{o}n del CIBERSAM ya no forman parte de \'{e}l, sus contribuciones tambi\'{e}n han favorecido el progreso de la investigaci\'{o}n en enfermedades mentales.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Hace 10 anos ˜ que el Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) nació con el objetivo principal de favorecer la investigación traslacional colaborativa de excelencia en salud mental. También hace 10 años que se puso en marcha la Revista de PsiquiatrÍa y Salud Mental. Dicha revista ha acompanado al CIBERSAM desde sus inicios y ha publicado más de 100 trabajos de investigadores del CIBERSAM. Por ello, hemos querido publicar este artículo que resume la trayectoria del CIBERSAM durante una década en la Revista de PsiquiatrÍa y Salud Mental. Concebido inicialmente como una red de investigación colaborativa (Red de Enfermedades Mentales, Trastornos Afectivos y Psicóticos [REM-TAP]), el CIBERSAM nació formalmente en 2007, y de forma efectiva en 2008, para integrar a los grupos de investigación básica y clínica en psiquiatría, salud mental y ciencias afines más destacados del país, como quedó plasmado en un número especial que, en 2009, le dedicó la revista The European Journal of Psychiatry1. El CIBERSAM tiene un carácter abierto, competitivo y meritocrático con base en criterios científicos, lo que lo convierte en una estructura dinámica, con evaluación anual y entrada y salida de grupos en función de su productividad. Aunque algunos grupos presentes en el momento de la creación del CIBERSAM ya no forman parte de él, sus contribuciones también han favorecido el progreso de la investigación en enfermedades mentales. |
2018 |
Martín-María, N; Caballero, FF ; Moreno-Agostino, D; Olaya, B; Haro, JM ; Ayuso-Mateos, JL ; Miret, M Relationship between subjective well-being and healthy lifestyle behaviours in older adults: a longitudinal study. Artículo de revista Aging & mental health, 1 (9), 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Mart\'{i}n-Mar\'{i}a2018, title = {Relationship between subjective well-being and healthy lifestyle behaviours in older adults: a longitudinal study. }, author = {Mart\'{i}n-Mar\'{i}a, N and Caballero, FF and Moreno-Agostino, D and Olaya, B and Haro, JM and Ayuso-Mateos, JL and Miret, M.}, url = {https://www.tandfonline.com/doi/full/10.1080/13607863.2018.1548567}, year = {2018}, date = {2018-12-28}, journal = {Aging & mental health}, volume = {1}, number = {9}, abstract = {Objectives: People who report better subjective well-being tend to be healthier in their daily behaviours. The objective of this study is to assess whether different components of subjective well-being are prospectively associated with different healthy lifestyle behaviours and to assess whether these associations differ by age. Method: A total of 1,892 participants aged 50+ living in Spain were interviewed in 2011\textendash12 and 2014\textendash15. Life satisfaction was measured with the Cantril Self-Anchoring Striving Scale. Positive and negative affect were assessed using the Day Reconstruction Method. Physical activity was assessed with the Global Physical Activity Questionnaire version 2. The remaining healthy lifestyle behaviours were self-reported. Generalised Estimating Equations (GEE) models were run. Results: Not having a heavy episodic alcohol drinking was the healthy lifestyle behaviour most fulfilled (97.97%), whereas the intake of five or more fruits and vegetables was the least followed (33.12%). GEE models conducted over the 50\textendash64 and the 65+ age groups showed that a higher life satisfaction was significantly related to a higher physical activity in both groups. Relationships between a higher negative affect and presenting a lower level of physical activity, and a higher positive affect and following the right consumption of fruits and vegetables and being a non-daily smoker, were only found in the older group. Conclusion: The relationship between subjective well-being and healthy lifestyle behaviours was found fundamentally in those aged 65+ years. Interventions focused on incrementing subjective well-being would have an impact on keeping a healthy lifestyle and, therefore, on reducing morbidity and mortality. Keywords: Positive affect, negative affect, life satisfaction, healthy lifestyle behaviours }, keywords = {}, pubstate = {published}, tppubtype = {article} } Objectives: People who report better subjective well-being tend to be healthier in their daily behaviours. The objective of this study is to assess whether different components of subjective well-being are prospectively associated with different healthy lifestyle behaviours and to assess whether these associations differ by age. Method: A total of 1,892 participants aged 50+ living in Spain were interviewed in 2011–12 and 2014–15. Life satisfaction was measured with the Cantril Self-Anchoring Striving Scale. Positive and negative affect were assessed using the Day Reconstruction Method. Physical activity was assessed with the Global Physical Activity Questionnaire version 2. The remaining healthy lifestyle behaviours were self-reported. Generalised Estimating Equations (GEE) models were run. Results: Not having a heavy episodic alcohol drinking was the healthy lifestyle behaviour most fulfilled (97.97%), whereas the intake of five or more fruits and vegetables was the least followed (33.12%). GEE models conducted over the 50–64 and the 65+ age groups showed that a higher life satisfaction was significantly related to a higher physical activity in both groups. Relationships between a higher negative affect and presenting a lower level of physical activity, and a higher positive affect and following the right consumption of fruits and vegetables and being a non-daily smoker, were only found in the older group. Conclusion: The relationship between subjective well-being and healthy lifestyle behaviours was found fundamentally in those aged 65+ years. Interventions focused on incrementing subjective well-being would have an impact on keeping a healthy lifestyle and, therefore, on reducing morbidity and mortality. Keywords: Positive affect, negative affect, life satisfaction, healthy lifestyle behaviours |
Koyanagi, A; Stubbs, B; Lara, E; Veronese, N; Vancampfort, D; Smith, L; Haro, J M; Oh, H; DeVylder, J E Psychotic experiences and subjective cognitive complaints among 224 842 people in 48 low- and middle-income countries Artículo de revista Epidemiol Psychiatr Sci, pp. 1–11, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30585571, title = {Psychotic experiences and subjective cognitive complaints among 224 842 people in 48 low- and middle-income countries}, author = {A Koyanagi and B Stubbs and E Lara and N Veronese and D Vancampfort and L Smith and J M Haro and H Oh and J E DeVylder}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30585571}, doi = { 10.1017/S2045796018000744}, year = {2018}, date = {2018-12-26}, journal = {Epidemiol Psychiatr Sci}, pages = {1--11}, abstract = {Abstract: AimsCognitive deficits are an important factor in the pathogenesis of psychosis. Subjective cognitive complaints (SCCs) are often considered to be a precursor of objective cognitive deficits, but there are no studies specifically on SCC and psychotic experiences (PE). Thus, we assessed the association between SCC and PE using data from 48 low- and middle-income countries. Methods: Community-based cross-sectional data of the World Health Survey were analysed. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 to 10 with higher scores representing more severe SCC. The Composite International Diagnostic Interview was used to identify past 12-month PE. Multivariable logistic regression and mediation analyses were performed. Results: The final sample consisted of 224 842 adults aged >18 years [mean (SD) age 38.3 (16.0) years; 49.3% males]. After adjustment for sociodemographic factors, a one-unit increase in the SCC scale was associated with a 1.17 (95% CI 1.16-1.18) times higher odds for PE in the overall sample, with this association being more pronounced in younger individuals: age 18-44 years OR = 1.19 (95% CI 1.17-1.20); 45-64 years OR = 1.15 (95% CI 1.12-1.17); \^{a}©¾65 years OR = 1.14 (95% CI 1.09-1.19). Collectively, other mental health conditions (perceived stress, depression, anxiety, sleep problems) explained 43.4% of this association, and chronic physical conditions partially explained the association but to a lesser extent (11.8%). Conclusions: SCC were associated with PE. Future longitudinal studies are needed to understand temporal associations and causal inferences, while the utility of SCC as a risk marker for psychosis especially for young adults should be scrutinised.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Abstract: AimsCognitive deficits are an important factor in the pathogenesis of psychosis. Subjective cognitive complaints (SCCs) are often considered to be a precursor of objective cognitive deficits, but there are no studies specifically on SCC and psychotic experiences (PE). Thus, we assessed the association between SCC and PE using data from 48 low- and middle-income countries. Methods: Community-based cross-sectional data of the World Health Survey were analysed. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 to 10 with higher scores representing more severe SCC. The Composite International Diagnostic Interview was used to identify past 12-month PE. Multivariable logistic regression and mediation analyses were performed. Results: The final sample consisted of 224 842 adults aged >18 years [mean (SD) age 38.3 (16.0) years; 49.3% males]. After adjustment for sociodemographic factors, a one-unit increase in the SCC scale was associated with a 1.17 (95% CI 1.16-1.18) times higher odds for PE in the overall sample, with this association being more pronounced in younger individuals: age 18-44 years OR = 1.19 (95% CI 1.17-1.20); 45-64 years OR = 1.15 (95% CI 1.12-1.17); ⩾65 years OR = 1.14 (95% CI 1.09-1.19). Collectively, other mental health conditions (perceived stress, depression, anxiety, sleep problems) explained 43.4% of this association, and chronic physical conditions partially explained the association but to a lesser extent (11.8%). Conclusions: SCC were associated with PE. Future longitudinal studies are needed to understand temporal associations and causal inferences, while the utility of SCC as a risk marker for psychosis especially for young adults should be scrutinised. |
de la Torre-Luque, A; de la Fuente, J; Prina, M; Sanchez-Niubo, A; Haro, J M; Ayuso-Mateos, J L Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors Artículo de revista J Affect Disord, 246 , pp. 329–337, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30594876, title = {Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors}, author = {A de la Torre-Luque and J de la Fuente and M Prina and A Sanchez-Niubo and J M Haro and J L Ayuso-Mateos}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30594876}, doi = { 10.1016/j.jad.2018.12.122}, year = {2018}, date = {2018-12-25}, journal = {J Affect Disord}, volume = {246}, pages = {329--337}, abstract = {Background: This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthy-ageing outcomes later in life. Methods: The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Results: Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. Conclusion: This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthy-ageing outcomes later in life. Methods: The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Results: Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. Conclusion: This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription. |
de la Fuente, J; Hjelmborg, J; Wod, M; de la Torre-Luque, A; Caballero, F F; Christensen, K; Ayuso-Mateos, J L Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modelling approach Artículo de revista J Gerontol B Psychol Sci Soc Sci, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30521005, title = {Longitudinal Associations of Sensory and Cognitive Functioning: A Structural Equation Modelling approach}, author = {J de la Fuente and J Hjelmborg and M Wod and A de la Torre-Luque and F F Caballero and K Christensen and J L Ayuso-Mateos}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Longitudinal+Associations+of+Sensory+and+Cognitive+Functioning%3A+A+Structural+Equation+Modelling+approach}, year = {2018}, date = {2018-12-06}, journal = {J Gerontol B Psychol Sci Soc Sci}, abstract = {Objetives Although visual and hearing impairments have been found to be associated with cognitive decline in the old age, the mechanism underlying this relationship remains unclear. This study aims at assessing the predictive role of visual and hearing difficulties on subsequent cognitive functioning. Method 3,508 individuals aged 60 and over from the cohort of the first (2002) and fifth waves (2010) of the English Longitudinal Study of Ageing (ELSA). Five self-reported visual and hearing functioning items were used to assess sensory functioning at baseline. Cognition was assessed eight years later by means of four measured tests covering immediate and delayed recall, verbal fluency, and processing speed. A Multiple Indicators Multiple Causes approach was used to assess the longitudinal associations of visual and hearing functioning with cognitive difficulties. A multi-group longitudinal measurement invariance was used to estimate latent change in cognitive difficulties across groups of participants presenting either visual, hearing, or dual sensory impairment (i.e., those reporting difficulties in both visual and hearing functioning items). Results Visual (\^{I}²=0.140, p<0.001) and hearing (\^{I}²=0.115, p<0.001) difficulties predicted cognitive difficulties eight years later. The latent increase in cognitive difficulties was steeper in people with visual impairment (d= 0.52, p<0.001), hearing impairment (d=0.50, p<0.001), and dual-sensory impairment (d=0.68, p<0.001) than those non-impaired (d=0.12, p<0.001). Discussion Visual and hearing difficulties were identified as predictors of subsequent cognitive decline in the old age. Interventions to prevent visual and hearing difficulties may have a substantial impact to slow down subsequent age-related cognitive decline.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Objetives Although visual and hearing impairments have been found to be associated with cognitive decline in the old age, the mechanism underlying this relationship remains unclear. This study aims at assessing the predictive role of visual and hearing difficulties on subsequent cognitive functioning. Method 3,508 individuals aged 60 and over from the cohort of the first (2002) and fifth waves (2010) of the English Longitudinal Study of Ageing (ELSA). Five self-reported visual and hearing functioning items were used to assess sensory functioning at baseline. Cognition was assessed eight years later by means of four measured tests covering immediate and delayed recall, verbal fluency, and processing speed. A Multiple Indicators Multiple Causes approach was used to assess the longitudinal associations of visual and hearing functioning with cognitive difficulties. A multi-group longitudinal measurement invariance was used to estimate latent change in cognitive difficulties across groups of participants presenting either visual, hearing, or dual sensory impairment (i.e., those reporting difficulties in both visual and hearing functioning items). Results Visual (β=0.140, p<0.001) and hearing (β=0.115, p<0.001) difficulties predicted cognitive difficulties eight years later. The latent increase in cognitive difficulties was steeper in people with visual impairment (d= 0.52, p<0.001), hearing impairment (d=0.50, p<0.001), and dual-sensory impairment (d=0.68, p<0.001) than those non-impaired (d=0.12, p<0.001). Discussion Visual and hearing difficulties were identified as predictors of subsequent cognitive decline in the old age. Interventions to prevent visual and hearing difficulties may have a substantial impact to slow down subsequent age-related cognitive decline. |
Domenech-Abella, J; Mundo, J; Leonardi, M; Chatterji, S; Tobiasz-Adamczyk, B; Koskinen, S; Ayuso-Mateos, JL ; Haro, J M The association between socioeconomic status and depression among older adults in Finland,Poland and Spain: A comparative cross-sectional study of distinct measures and pathways Artículo de revista Journal of affective disorders, 1 (241), pp. 311-318, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Domenech-Abella2018, title = {The association between socioeconomic status and depression among older adults in Finland,Poland and Spain: A comparative cross-sectional study of distinct measures and pathways}, author = {Domenech-Abella, J and Mundo, J and Leonardi, M and Chatterji, S and Tobiasz-Adamczyk, B and Koskinen, S and Ayuso-Mateos, JL and Haro, J. M. }, url = {https://www.ncbi.nlm.nih.gov/pubmed/30142590}, doi = {10.1016/j.jad.2018.08.077}, year = {2018}, date = {2018-12-05}, journal = {Journal of affective disorders}, volume = {1}, number = {241}, pages = {311-318}, abstract = {BACKGROUND: Socioeconomic status, as measured by education, occupation or income, is associated with depression. However, data are lacking on the psychosocial, material and behavioral mediators of these associations. We have examined the association of education, occupation and income with depression and the potential mediations using community-based data. METHODS: A total of 7,966 older adults were interviewed in Finland, Poland and Spain. The differential associations between depression and SES, mediator variables, country of residence and cofounder variables, such as chronic physical conditions, were assessed through logistic regression models. Meditation analyses were carried out using khb method for Stata 13.1. RESULTS: Education, followed by household income, were the SES indicators most frequently significantly associated with depression. These SES markers, but not occupation, showed an independent effect in this association. Psychosocial factors and loneliness in particular showed the strongest associations with depression among mediator variables. However, material factors and, especially, financial strain had a higher mediating function in the association between SES and depression. Overall, SES markers, chronic conditions and mediation factors were more positive in Finland than in Poland and Spain. CONCLUSION: Improving psychosocial and material dimensions as well as access to the educational system for older adults might result in a reduction in the prevalence of depression in the general population and particularly among individuals with low SES.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: Socioeconomic status, as measured by education, occupation or income, is associated with depression. However, data are lacking on the psychosocial, material and behavioral mediators of these associations. We have examined the association of education, occupation and income with depression and the potential mediations using community-based data. METHODS: A total of 7,966 older adults were interviewed in Finland, Poland and Spain. The differential associations between depression and SES, mediator variables, country of residence and cofounder variables, such as chronic physical conditions, were assessed through logistic regression models. Meditation analyses were carried out using khb method for Stata 13.1. RESULTS: Education, followed by household income, were the SES indicators most frequently significantly associated with depression. These SES markers, but not occupation, showed an independent effect in this association. Psychosocial factors and loneliness in particular showed the strongest associations with depression among mediator variables. However, material factors and, especially, financial strain had a higher mediating function in the association between SES and depression. Overall, SES markers, chronic conditions and mediation factors were more positive in Finland than in Poland and Spain. CONCLUSION: Improving psychosocial and material dimensions as well as access to the educational system for older adults might result in a reduction in the prevalence of depression in the general population and particularly among individuals with low SES. |
Dimopoulos, A C; Nikolaidou, M; Caballero, F F; Engchuan, W; Sanchez-Niubo, A; Arndt, H; Ayuso-Mateos, JL ; Haro, JM ; Chatterji, S; Georgousopoulou, EN ; Pitsavos Cand Panagiotakos, D B Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. Artículo de revista BMC Med Res Methodol., 18 (1), pp. 179, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Dimopoulos2018, title = {Machine learning methodologies versus cardiovascular risk scores, in predicting disease risk. }, author = {Dimopoulos, A. C and Nikolaidou, M and Caballero, F. F and Engchuan, W and Sanchez-Niubo, A and Arndt, H and Ayuso-Mateos, JL and Haro, JM and Chatterji, S and Georgousopoulou, EN and Pitsavos, Cand Panagiotakos, D. B. }, url = {https://www.ncbi.nlm.nih.gov/pubmed/30594138}, doi = {10.1186/s12874-018-0644-1}, year = {2018}, date = {2018-12-04}, journal = {BMC Med Res Methodol.}, volume = {18}, number = {1}, pages = {179}, abstract = {BACKGROUND: The use of Cardiovascular Disease (CVD) risk estimation scores in primary prevention has long been established. However, their performance still remains a matter of concern. The aim of this study was to explore the potential of using ML methodologies on CVD prediction, especially compared to established risk tool, the HellenicSCORE. METHODS: Data from the ATTICA prospective study (n = 2020 adults), enrolled during 2001-02 and followed-up in 2011-12 were used. Three different machine-learning classifiers (k-NN, random forest, and decision tree) were trained and evaluated against 10-year CVD incidence, in comparison with the HellenicSCORE tool (a calibration of the ESC SCORE). Training datasets, consisting from 16 variables to only 5 variables, were chosen, with or without bootstrapping, in an attempt to achieve the best overall performance for the machine learning classifiers. RESULTS: Depending on the classifier and the training dataset the outcome varied in efficiency but was comparable between the two methodological approaches. In particular, the HellenicSCORE showed accuracy 85%, specificity 20%, sensitivity 97%, positive predictive value 87%, and negative predictive value 58%, whereas for the machine learning methodologies, accuracy ranged from 65 to 84%, specificity from 46 to 56%, sensitivity from 67 to 89%, positive predictive value from 89 to 91%, and negative predictive value from 24 to 45%; random forest gave the best results, while the k-NN gave the poorest results. CONCLUSIONS: The alternative approach of machine learning classification produced results comparable to that of risk prediction scores and, thus, it can be used as a method of CVD prediction, taking into consideration the advantages that machine learning methodologies may offer.}, keywords = {}, pubstate = {published}, tppubtype = {article} } BACKGROUND: The use of Cardiovascular Disease (CVD) risk estimation scores in primary prevention has long been established. However, their performance still remains a matter of concern. The aim of this study was to explore the potential of using ML methodologies on CVD prediction, especially compared to established risk tool, the HellenicSCORE. METHODS: Data from the ATTICA prospective study (n = 2020 adults), enrolled during 2001-02 and followed-up in 2011-12 were used. Three different machine-learning classifiers (k-NN, random forest, and decision tree) were trained and evaluated against 10-year CVD incidence, in comparison with the HellenicSCORE tool (a calibration of the ESC SCORE). Training datasets, consisting from 16 variables to only 5 variables, were chosen, with or without bootstrapping, in an attempt to achieve the best overall performance for the machine learning classifiers. RESULTS: Depending on the classifier and the training dataset the outcome varied in efficiency but was comparable between the two methodological approaches. In particular, the HellenicSCORE showed accuracy 85%, specificity 20%, sensitivity 97%, positive predictive value 87%, and negative predictive value 58%, whereas for the machine learning methodologies, accuracy ranged from 65 to 84%, specificity from 46 to 56%, sensitivity from 67 to 89%, positive predictive value from 89 to 91%, and negative predictive value from 24 to 45%; random forest gave the best results, while the k-NN gave the poorest results. CONCLUSIONS: The alternative approach of machine learning classification produced results comparable to that of risk prediction scores and, thus, it can be used as a method of CVD prediction, taking into consideration the advantages that machine learning methodologies may offer. |
Kollia, N; Caballero, F F; Sanchez-Niubo, A; Tyrovolas, S; Ayuso-Mateos, J L; Haro, J M; Chatterji, S; Panagiotakos, D B Social determinants, health status and 10-year mortality among 10,906 older adults from the English longitudinal study of aging: the AŦĦLOS project Artículo de revista BMC Public Health, 18 (1), pp. 1357, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30526556, title = {Social determinants, health status and 10-year mortality among 10,906 older adults from the English longitudinal study of aging: the A{T}{H}LOS project}, author = {N Kollia and F F Caballero and A Sanchez-Niubo and S Tyrovolas and J L Ayuso-Mateos and J M Haro and S Chatterji and D B Panagiotakos}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Social+determinants%2C+health+status+and+10-year+mortality+among+10%2C906+older+adults+from+the+English+longitudinal+study+of+aging%3A+the+A%C5%A6%C4%A6LOS+project}, doi = {10.1186/s12889-018-6288-6.}, year = {2018}, date = {2018-12-01}, journal = {BMC Public Health}, volume = {18}, number = {1}, pages = {1357}, abstract = {In either rich or poor countries, people's health widely depends on the social conditions in which they live and work - the social determinants of health. The aim of the present work was to explore the association of educational and financial status with healthy aging and mortality. Data from the English Longitudinal Study of Aging (ELSA) were studied (n = 10,906 participants, 64 ± 11 years, 55% women). A set of 45 self-reported health items and measured tests were used to generate a latent health metric reflecting levels of functioning referred to as health metric (higher values indicated better health status). Overall mortality after 10-years of follow-up (2002-2012) was recorded. Both education and household wealth over time were positively associated with the health metric (p < 0.001) and negatively with overall mortality (p < 0.001). Lifestyle behaviors (i.e., physical activity, smoking habits and alcohol consumption) mediated the effect of education and household wealth on the health metric and the latter mediated their effect on overall mortality. In conclusion, reducing socioeconomic disparities in health by improving the access to education and by providing financial opportunities should be among the priorities in improving the health of older adults.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In either rich or poor countries, people's health widely depends on the social conditions in which they live and work - the social determinants of health. The aim of the present work was to explore the association of educational and financial status with healthy aging and mortality. Data from the English Longitudinal Study of Aging (ELSA) were studied (n = 10,906 participants, 64 ± 11 years, 55% women). A set of 45 self-reported health items and measured tests were used to generate a latent health metric reflecting levels of functioning referred to as health metric (higher values indicated better health status). Overall mortality after 10-years of follow-up (2002-2012) was recorded. Both education and household wealth over time were positively associated with the health metric (p < 0.001) and negatively with overall mortality (p < 0.001). Lifestyle behaviors (i.e., physical activity, smoking habits and alcohol consumption) mediated the effect of education and household wealth on the health metric and the latter mediated their effect on overall mortality. In conclusion, reducing socioeconomic disparities in health by improving the access to education and by providing financial opportunities should be among the priorities in improving the health of older adults. |
Cresswell‑Smith, J; Amaddeo, F; Donisi, V; Forsman, A K; Kalseth, J; Martin‑Maria, N; Miret, M; Walhbeck, K Determinants of multidimensional mental wellbeing in the oldest old: a rapid review Artículo de revista Social Psychiatry and Psychiatric Epidemiology , 2018, ISSN: 1433-9285. Resumen | Enlaces | BibTeX | Etiquetas: @article{Cresswell‑Smith2018, title = {Determinants of multidimensional mental wellbeing in the oldest old: a rapid review}, author = {J Cresswell‑Smith and F Amaddeo and V Donisi and A K Forsman and J Kalseth and N Martin‑Maria and M Miret and K Walhbeck}, url = {https://link.springer.com/article/10.1007%2Fs00127-018-1633-8#citeas}, doi = {doi.org/10.1007/s00127-018-1633-8}, issn = {1433-9285}, year = {2018}, date = {2018-11-29}, journal = {Social Psychiatry and Psychiatric Epidemiology }, abstract = {Purpose Improved life expectancy imposes new challenges for policy-makers. The growing oldest-old age group (defined as 80 and over) is often characterised by increased support needs. Greater attention to wellbeing in this population group is necessary, and may well require a shift in social policy focus. The current review seeks to explore current research on determinants of mental wellbeing for the oldest old. Methods An iterative rapid review approach was used to review existing literature in line with four dimensions of mental wellbeing defined by the European Welfare Models and Mental Wellbeing in Final Years of Life (EMMY) study; functional, social, personal and environmental. A specific focus on articles employing multidimensional definitions of mental wellbeing was adopted. Results Multidimensional indicators reflect the multifaceted and multidirectional dynamics of wellbeing in very old age. Considerable variety in both measures and terminology was found within the literature making precise comparison difficult. The current review takes steps towards comparability by focusing on studies implementing multiple measures of mental wellbeing including evaluative, hedonistic and eudaimonic factors. Clearly defined and multifaceted measures of mental wellbeing are needed to sharpen evidence used in policy development, appraisal and evaluation in light of the considerable diversity of health and functional states experienced in later life. Conclusions Previous studies appear to line up the four main dimensions of mental wellbeing identified in the EMMY study. Actively improving opportunities for older adults to produce benefits to society can be done via a stronger focus on resources such as mental wellbeing.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Purpose Improved life expectancy imposes new challenges for policy-makers. The growing oldest-old age group (defined as 80 and over) is often characterised by increased support needs. Greater attention to wellbeing in this population group is necessary, and may well require a shift in social policy focus. The current review seeks to explore current research on determinants of mental wellbeing for the oldest old. Methods An iterative rapid review approach was used to review existing literature in line with four dimensions of mental wellbeing defined by the European Welfare Models and Mental Wellbeing in Final Years of Life (EMMY) study; functional, social, personal and environmental. A specific focus on articles employing multidimensional definitions of mental wellbeing was adopted. Results Multidimensional indicators reflect the multifaceted and multidirectional dynamics of wellbeing in very old age. Considerable variety in both measures and terminology was found within the literature making precise comparison difficult. The current review takes steps towards comparability by focusing on studies implementing multiple measures of mental wellbeing including evaluative, hedonistic and eudaimonic factors. Clearly defined and multifaceted measures of mental wellbeing are needed to sharpen evidence used in policy development, appraisal and evaluation in light of the considerable diversity of health and functional states experienced in later life. Conclusions Previous studies appear to line up the four main dimensions of mental wellbeing identified in the EMMY study. Actively improving opportunities for older adults to produce benefits to society can be done via a stronger focus on resources such as mental wellbeing. |
Salagre, E; Arango, C; Artigas, F; Ayuso-Mateos, J L; Bernardo, M; Castro-Fornieles, J; Bobes, J; Desco, M; Fananas, L; Gonzalez-Pinto, A; Haro, J M; Leza, J C; Mckenna, P J; Meana, J J; Menchon, J M; Mico, J A; Palomo, T; Pazos, A; Perez, V; Saiz-Ruiz, J; Sanjuan, J; Tabares-Seisdedos, R; Crespo-Facorro, B; Casas, M; Vilella, E; Palao, D; Olivares, J M; Rodriguez-Jimenez, R; Vieta, E CIBERSAM: Ten years of collaborative translational research in mental disorders Artículo de revista Rev Psiquiatr Salud Ment, 2018. @article{pmid30416047, title = {CIBERSAM: Ten years of collaborative translational research in mental disorders}, author = {E Salagre and C Arango and F Artigas and J L Ayuso-Mateos and M Bernardo and J Castro-Fornieles and J Bobes and M Desco and L Fananas and A Gonzalez-Pinto and J M Haro and J C Leza and P J Mckenna and J J Meana and J M Menchon and J A Mico and T Palomo and A Pazos and V Perez and J Saiz-Ruiz and J Sanjuan and R Tabares-Seisdedos and B Crespo-Facorro and M Casas and E Vilella and D Palao and J M Olivares and R Rodriguez-Jimenez and E Vieta}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30416047}, doi = {10.1016/j.rpsm.2018.10.001}, year = {2018}, date = {2018-11-08}, journal = {Rev Psiquiatr Salud Ment}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Daskalopoulou, C; Koukounari, A; Ayuso-Mateos, J L; Prince, M; Prina, A M Associations of lifestyle behaviour and healthy ageing in five Latin American and the Caribbean countries - A 10/66 population-based cohort study Artículo de revista Nutrients, 10 (11), 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Daskalopoulou2018, title = {Associations of lifestyle behaviour and healthy ageing in five Latin American and the Caribbean countries - A 10/66 population-based cohort study}, author = {C Daskalopoulou and A Koukounari and J.L Ayuso-Mateos and M Prince and A. M Prina}, url = {https://www.mdpi.com/2072-6643/10/11/1593 https://www.ncbi.nlm.nih.gov/pubmed/30380734}, year = {2018}, date = {2018-10-30}, journal = {Nutrients}, volume = {10}, number = {11}, abstract = {Latin American and the Caribbean countries exhibit high life expectancy and projections show that they will experience the fastest growth of older people in the following years. As people live longer, it is important to maximise the opportunity to age healthily. We aimed to examine the associations of lifestyle behaviours with healthy ageing in Cuba, Dominican Republic, Peru, Mexico and Puerto Rico, part of the 10/66 study. Residents 65 years old and over (n = 10,900) were interviewed between 2003 and 2010. In the baseline survey, we measured four healthy behaviours: Physical activity, non-smoking, moderate drinking and fruits or vegetables consumption. Healthy ageing was conceptualised within the functional ability framework over a median of 4 years follow-up. Logistic models were calculated per country and then pooled together with fixed-effects meta-analysis. People engaging in physical activity and consuming fruits or vegetables had increased odds of healthy ageing in the follow-up (OR: 2.59, 95% CI: 2.20\textendash3.03; OR: 1.24, 95% CI: 1.06\textendash1.44, respectively). Compared with participants engaging in none or one healthy behaviour, the ORs of participants engaging in two, three or four healthy behaviours increased in a linear way (OR: 1.60, 95% CI: 1.40\textendash1.84; OR: 2.29, 95% CI: 1.94\textendash2.69; OR: 2.46, 95% CI: 1.54\textendash3.92, respectively). Our findings highlight the importance of awareness of a healthy lifestyle behaviour among older people.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Latin American and the Caribbean countries exhibit high life expectancy and projections show that they will experience the fastest growth of older people in the following years. As people live longer, it is important to maximise the opportunity to age healthily. We aimed to examine the associations of lifestyle behaviours with healthy ageing in Cuba, Dominican Republic, Peru, Mexico and Puerto Rico, part of the 10/66 study. Residents 65 years old and over (n = 10,900) were interviewed between 2003 and 2010. In the baseline survey, we measured four healthy behaviours: Physical activity, non-smoking, moderate drinking and fruits or vegetables consumption. Healthy ageing was conceptualised within the functional ability framework over a median of 4 years follow-up. Logistic models were calculated per country and then pooled together with fixed-effects meta-analysis. People engaging in physical activity and consuming fruits or vegetables had increased odds of healthy ageing in the follow-up (OR: 2.59, 95% CI: 2.20–3.03; OR: 1.24, 95% CI: 1.06–1.44, respectively). Compared with participants engaging in none or one healthy behaviour, the ORs of participants engaging in two, three or four healthy behaviours increased in a linear way (OR: 1.60, 95% CI: 1.40–1.84; OR: 2.29, 95% CI: 1.94–2.69; OR: 2.46, 95% CI: 1.54–3.92, respectively). Our findings highlight the importance of awareness of a healthy lifestyle behaviour among older people. |
Reed, G M; Sharan, P; Rebello, T J; Keeley, J W; Medina-Mora, M E; Gureje, O; Ayuso-Mateos, J L; Kanba, S; Khoury, B; Kogan, C S; Krasnov, V N; Maj, M; de Mari, Jesus J; Stein, DJ; Zhao, M; Akiyama, T; Andrews, H F; Asevedo, E; Cheour, M; Domínguez-Martínez, T; El-Khoury, J; Fiorillo, A; Grenier, J; Gupta, N; Kola, L; Kulygina, M; Leal-Leturia, I; Luciano, M; Lusu, B; Nicolas, J; Martínez-López, I; Matsumoto, C; Onofa, Umukoro L; Paterniti, S; Purnima, S; Robles, R; Sahu, M K; Sibeko, G; Zhong, N; First, M B; Gaebel, W; Lovell, AM; Maruta, T; Roberts, M C; Pike, K M Clinical utility of ICD-11 diagnostic guidelines for high-burden mental disorders: results from mental health settings in 13 countries Artículo de revista World Psychiatry, (3), pp. 306-315, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Reed0000, title = {Clinical utility of ICD-11 diagnostic guidelines for high-burden mental disorders: results from mental health settings in 13 countries}, author = {G M Reed and P Sharan and T J Rebello and J W Keeley and M E Medina-Mora and O Gureje and J L Ayuso-Mateos and S Kanba and B Khoury and C S Kogan and V N Krasnov and M Maj and J de Jesus Mari and DJ Stein and M Zhao and T Akiyama and H F Andrews and E Asevedo and M Cheour and T Dom\'{i}nguez-Mart\'{i}nez and J El-Khoury and A Fiorillo and J Grenier and N Gupta and L Kola and M Kulygina and I Leal-Leturia and M Luciano and B Lusu and J Nicolas and I Mart\'{i}nez-L\'{o}pez and C Matsumoto and L Umukoro Onofa and S Paterniti and S Purnima and R Robles and M K Sahu and G Sibeko and N Zhong and M B First and W Gaebel and AM Lovell and T Maruta and M C Roberts and K M Pike}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30192090}, doi = {10.1002/wps.20581}, year = {2018}, date = {2018-10-17}, journal = {World Psychiatry}, number = {3}, pages = {306-315}, publisher = {John Wiley and Sons Inc.}, abstract = {In this paper we report the clinical utility of the clinical descriptions and diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients in 28 mental health settings in 13 countries. Clinician raters applied the guidelines for schizophrenia and other primary psychotic disorders, mood disorders (depressive and bipolar disorders), anxiety and fear-related disorders, and disorders specifically associated with stress. Clinician ratings of the clinical utility of the proposed ICD-11 diagnostic guidelines were very positive overall. The guidelines were perceived as easy to use, corresponding accurately to patients’ presentations (i.e., goodness of fit), clear and understandable, providing an appropriate level of detail, taking about the same or less time than clinicians’ usual practice, and providing useful guidance about distinguishing disorder from normality and from other disorders. Clinicians evaluated the guidelines as less useful for treatment selection and assessing prognosis than for communicating with other health professionals, though the former ratings were still positive overall. Field studies that assess perceived clinical utility of the proposed ICD-11 clinical descriptions and diagnostic guidelines among its intended users have very important implications. Classification is the interface between health encounters and health information; if clinicians do not feel that a new diagnostic system provides clinically useful information, they are unlikely to apply it consistently and faithfully. This will have major implications for the validity of aggregated health encounter data used for health policy and decision making. Overall, the results of this study provide considerable reason to be optimistic about the perceived clinical utility of the ICD-11 among global clinicians.}, keywords = {}, pubstate = {published}, tppubtype = {article} } In this paper we report the clinical utility of the clinical descriptions and diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients in 28 mental health settings in 13 countries. Clinician raters applied the guidelines for schizophrenia and other primary psychotic disorders, mood disorders (depressive and bipolar disorders), anxiety and fear-related disorders, and disorders specifically associated with stress. Clinician ratings of the clinical utility of the proposed ICD-11 diagnostic guidelines were very positive overall. The guidelines were perceived as easy to use, corresponding accurately to patients’ presentations (i.e., goodness of fit), clear and understandable, providing an appropriate level of detail, taking about the same or less time than clinicians’ usual practice, and providing useful guidance about distinguishing disorder from normality and from other disorders. Clinicians evaluated the guidelines as less useful for treatment selection and assessing prognosis than for communicating with other health professionals, though the former ratings were still positive overall. Field studies that assess perceived clinical utility of the proposed ICD-11 clinical descriptions and diagnostic guidelines among its intended users have very important implications. Classification is the interface between health encounters and health information; if clinicians do not feel that a new diagnostic system provides clinically useful information, they are unlikely to apply it consistently and faithfully. This will have major implications for the validity of aggregated health encounter data used for health policy and decision making. Overall, the results of this study provide considerable reason to be optimistic about the perceived clinical utility of the ICD-11 among global clinicians. |
Vancampfort, D; Stubbs, B; Lara, E; Vandenbulcke, M; Swinnen, N; Koyanagi, A Correlates of sedentary behavior in middle-aged and old age people with mild cognitive impairment: a multinational study Artículo de revista International Psychogeriatrics, 2018, ISSN: 1041-6102. Resumen | Enlaces | BibTeX | Etiquetas: @article{D2018, title = {Correlates of sedentary behavior in middle-aged and old age people with mild cognitive impairment: a multinational study}, author = {D Vancampfort and B Stubbs and E Lara and M Vandenbulcke and N Swinnen and A Koyanagi }, url = {https://www.cambridge.org/core/journals/international-psychogeriatrics/article/correlates-of-sedentary-behavior-in-middleaged-and-old-age-people-with-mild-cognitive-impairment-a-multinational-study/F9960A517991557B11E0E84DE4A54AF7}, doi = {doi:10.1017/S1041610218001163}, issn = {1041-6102}, year = {2018}, date = {2018-10-16}, journal = {International Psychogeriatrics}, abstract = {Objective: Despite the benefits of being active for people with mild cognitive impairment (MCI) on cognition and the acknowledgement that MCI is a critical period for intervening to prevent dementia, little is known about the actual sedentary levels in people with MCI. This study investigates correlates of sedentary behavior (SB) in people with MCI. Design: This was a cross-sectional study. Setting: Data from the World Health Organization’s Study on Global Ageing and Adult Health were analyzed. Participants: Individuals aged ≥50 years with MCI were included. Measurements: SB was assessed by the Global Physical Activity Questionnaire. Associations between SB levels and the correlates were examined using multivariable linear and logistic regressions. Results: 4,082 individuals aged ≥50 years with MCI (64.4 ± 17.0 years; 55.1% female) were included. The prevalence of high SB (i.e., ≥8 hours/day) was 14.0% (95%CI = 12.2%\textendash16.0%), while the time spent sedentary was 262 ± 290 minutes/day. Correlates significantly associated with being sedentary ≥8 hours/day and time spent sedentary per day were, older age, being unemployed, depression, sleep problems, obesity (vs. normal weight), diabetes, stroke, poor self-rated health, and lower levels of social cohesion. Conclusions: Future research exploring interventions to reduce SB in people with MCI should target the identified sociodemographic and mental and physical health correlates, while the promotion of social cohesion may have the potential to increase the efficacy of future public health initiatives.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Objective: Despite the benefits of being active for people with mild cognitive impairment (MCI) on cognition and the acknowledgement that MCI is a critical period for intervening to prevent dementia, little is known about the actual sedentary levels in people with MCI. This study investigates correlates of sedentary behavior (SB) in people with MCI. Design: This was a cross-sectional study. Setting: Data from the World Health Organization’s Study on Global Ageing and Adult Health were analyzed. Participants: Individuals aged ≥50 years with MCI were included. Measurements: SB was assessed by the Global Physical Activity Questionnaire. Associations between SB levels and the correlates were examined using multivariable linear and logistic regressions. Results: 4,082 individuals aged ≥50 years with MCI (64.4 ± 17.0 years; 55.1% female) were included. The prevalence of high SB (i.e., ≥8 hours/day) was 14.0% (95%CI = 12.2%–16.0%), while the time spent sedentary was 262 ± 290 minutes/day. Correlates significantly associated with being sedentary ≥8 hours/day and time spent sedentary per day were, older age, being unemployed, depression, sleep problems, obesity (vs. normal weight), diabetes, stroke, poor self-rated health, and lower levels of social cohesion. Conclusions: Future research exploring interventions to reduce SB in people with MCI should target the identified sociodemographic and mental and physical health correlates, while the promotion of social cohesion may have the potential to increase the efficacy of future public health initiatives. |
Moreno-Agostino, D; Caballero, F F; Martin-Maria, N; Tyrovolas, S; Lopez-Garcia, P; Rodriguez-Artalejo, F; Haro, J M; Ayuso-Mateos, J L; Miret, M Mediterranean diet and wellbeing: evidence from a nationwide survey Artículo de revista Psychol Health, pp. 1-15, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30320519, title = {Mediterranean diet and wellbeing: evidence from a nationwide survey}, author = {D Moreno-Agostino and F F Caballero and N Martin-Maria and S Tyrovolas and P Lopez-Garcia and F Rodriguez-Artalejo and J M Haro and J L Ayuso-Mateos and M Miret}, url = {https://www.tandfonline.com/doi/abs/10.1080/08870446.2018.1525492?journalCode=gpsh20 https://www.ncbi.nlm.nih.gov/pubmed/30320519}, year = {2018}, date = {2018-10-15}, journal = {Psychol Health}, pages = {1-15}, abstract = {Although there is some evidence of the association between specific food groups, such as plant foods, and subjective wellbeing, this is the first study to assess the relationship between adherence to the Mediterranean dietary pattern and subjective wellbeing. Data were collected in 2014-2015, within the Edad con Salud project, a follow-up study of a multistage clustered survey on a representative sample of the population of Spain. The final sample comprised 2397 individuals with ages ranging from 21 to 101 years. Experienced wellbeing (positive and negative affect) was measured using the Day Reconstruction Method, and evaluative wellbeing was assessed with the Cantril Self-Anchoring Striving Scale. A higher adherence to the Mediterranean diet showed a small but statistically significant inverse relationship with negative affect (\^{I}² = -0.076}, keywords = {}, pubstate = {published}, tppubtype = {article} } Although there is some evidence of the association between specific food groups, such as plant foods, and subjective wellbeing, this is the first study to assess the relationship between adherence to the Mediterranean dietary pattern and subjective wellbeing. Data were collected in 2014-2015, within the Edad con Salud project, a follow-up study of a multistage clustered survey on a representative sample of the population of Spain. The final sample comprised 2397 individuals with ages ranging from 21 to 101 years. Experienced wellbeing (positive and negative affect) was measured using the Day Reconstruction Method, and evaluative wellbeing was assessed with the Cantril Self-Anchoring Striving Scale. A higher adherence to the Mediterranean diet showed a small but statistically significant inverse relationship with negative affect (β = -0.076 |
Son, Mayoral-van J; Juncal-Ruiz, M; de la Foz, Ortiz-Garcia V; Cantarero-Prieto, D; Blazquez-Fernandez, C; Paz-Zulueta, M; Paras-Bravo, P; Ayuso-Mateos, J L; Crespo-Facorro, B Understanding the direct and indirect costs of a first episode of psychosis program: Insights from PAFIP of Cantabria, Spain, during the first year of intervention Artículo de revista Early Interv Psychiatry, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30311416, title = {Understanding the direct and indirect costs of a first episode of psychosis program: Insights from PAFIP of Cantabria, Spain, during the first year of intervention}, author = {J Mayoral-van Son and M Juncal-Ruiz and V Ortiz-Garcia de la Foz and D Cantarero-Prieto and C Blazquez-Fernandez and M Paz-Zulueta and P Paras-Bravo and J L Ayuso-Mateos and B Crespo-Facorro}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30311416}, doi = {10.1111/eip.12752}, year = {2018}, date = {2018-10-12}, journal = {Early Interv Psychiatry}, abstract = {Early intervention psychiatric services for patients with psychosis aim to limit the most damaging outcomes and reduce the patient's risk of social drift, decreasing illness severity and thus containing healthcare costs. There is a scarcity of studies that focus on first-episode psychosis (FEP), and those few that have been published only looked at direct health costs, but not at indirect costs, which make up the bulk of the budget. Our study aims to explore the short-term (1-year follow-up) economic cost of a FEP Program, including both direct and indirect costs. Data were collected retrospectively from the clinical records of 157 patients included in the Programa Atenci\~{A}³n Fases Iniciales de Psicosis, from Marqu\~{A}©s de Valdecilla University Hospital, Santander. Our data collection sheet collated data from direct and indirect costs associated with the illness. Data were also extracted from the Cantabria Health Service Records. STATA 15.0 was used for statistical analysis. On average, the total costs during the first year were \^{a}‚¬48 353.51 per patient, with direct healthcare costs being \^{a}‚¬13 729.47 (28.39%), direct non-medical costs \^{a}‚¬108.6 (0.22%), and indirect costs \^{a}‚¬34 515.44 (71.39%). We found that hospitalization costs were higher in males (p = 0.081) and in cannabis users (p = 0.032). The number of relapses increased both, hospitalization and treatment costs (r = 0.40 p = 0.000; r = 0.24 p = 0.067, respectively). Intensive Early Intervention in Psychosis Services may result in cost savings by decreasing hospitalization, premature mortality, disability, unemployment, and legal problems; however, the first year after diagnosis would represent the one with the highest costs.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Early intervention psychiatric services for patients with psychosis aim to limit the most damaging outcomes and reduce the patient's risk of social drift, decreasing illness severity and thus containing healthcare costs. There is a scarcity of studies that focus on first-episode psychosis (FEP), and those few that have been published only looked at direct health costs, but not at indirect costs, which make up the bulk of the budget. Our study aims to explore the short-term (1-year follow-up) economic cost of a FEP Program, including both direct and indirect costs. Data were collected retrospectively from the clinical records of 157 patients included in the Programa Atención Fases Iniciales de Psicosis, from Marqués de Valdecilla University Hospital, Santander. Our data collection sheet collated data from direct and indirect costs associated with the illness. Data were also extracted from the Cantabria Health Service Records. STATA 15.0 was used for statistical analysis. On average, the total costs during the first year were €48 353.51 per patient, with direct healthcare costs being €13 729.47 (28.39%), direct non-medical costs €108.6 (0.22%), and indirect costs €34 515.44 (71.39%). We found that hospitalization costs were higher in males (p = 0.081) and in cannabis users (p = 0.032). The number of relapses increased both, hospitalization and treatment costs (r = 0.40 p = 0.000; r = 0.24 p = 0.067, respectively). Intensive Early Intervention in Psychosis Services may result in cost savings by decreasing hospitalization, premature mortality, disability, unemployment, and legal problems; however, the first year after diagnosis would represent the one with the highest costs. |
Koyanagi, A; Oh, H; Vancampfort, D; Carvalho, A F; Veronese, N; Stubbs, B; Lara, E Perceived Stress and Mild Cognitive Impairment among 32,715 Community-Đwelling Older Adults across Six Low- and Middle-Income Countries Artículo de revista Gerontology, (10), pp. 1–9, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30199870, title = {Perceived Stress and Mild Cognitive Impairment among 32,715 Community-{D}welling Older Adults across Six Low- and Middle-Income Countries}, author = {A Koyanagi and H Oh and D Vancampfort and A F Carvalho and N Veronese and B Stubbs and E Lara}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30199870}, year = {2018}, date = {2018-09-10}, journal = {Gerontology}, number = {10}, pages = {1--9}, abstract = {Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa) using nationally representative data. Cross-sectional, community-based data on individuals aged \^{a}‰¥50 years from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. A perceived stress score (range 0 [lowest stress] to 10 [highest stress]) was computed based on two questions from the Perceived Stress Scale. Multivariable logistic regression analysis was conducted to assess the as-sociation between perceived stress and MCI. The mean (SD) age of the 32,715 participants was 62.1 (15.6) years and 51.7% were females. After adjustment for potential confounders including depression, in the overall sample, a one-unit increase in the perceived stress score was associated with a 1.14 (95% CI = 1.11-1.18) times higher odds for MCI. The association was similar among those aged 50-64 and \^{a}‰¥65 years. Countrywise analysis showed that there was a moderate level of between-country heterogeneity in this association (I2 = 59.4%), with the strongest association observed in Russia (OR = 1.33, 95% CI = 1.15-1.55). If our study results are confirmed in prospective studies, addressing perceived stress may have an impact in reducing the risk for MCI and subsequent dementia in LMICs.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Perceived stress may be a modifiable risk factor for mild cognitive impairment (MCI) and ultimately dementia, but studies on this topic from low- and middle-income countries (LMICs) are lacking. We assessed the association between perceived stress and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa) using nationally representative data. Cross-sectional, community-based data on individuals aged ≥50 years from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. A perceived stress score (range 0 [lowest stress] to 10 [highest stress]) was computed based on two questions from the Perceived Stress Scale. Multivariable logistic regression analysis was conducted to assess the as-sociation between perceived stress and MCI. The mean (SD) age of the 32,715 participants was 62.1 (15.6) years and 51.7% were females. After adjustment for potential confounders including depression, in the overall sample, a one-unit increase in the perceived stress score was associated with a 1.14 (95% CI = 1.11-1.18) times higher odds for MCI. The association was similar among those aged 50-64 and ≥65 years. Countrywise analysis showed that there was a moderate level of between-country heterogeneity in this association (I2 = 59.4%), with the strongest association observed in Russia (OR = 1.33, 95% CI = 1.15-1.55). If our study results are confirmed in prospective studies, addressing perceived stress may have an impact in reducing the risk for MCI and subsequent dementia in LMICs. |
Canal, M; López, J D; Setién, E; Ruiz, M; Ayuso-Mateos, J L; Ayesa, R; Crespo-Facorroa, B Predicting suicidal behaviour after first episode of non-affective psychosis: The role of neurocognitive functioning Artículo de revista En preparación European Psychiatry, 53 , pp. 52-57, En preparación, ISBN: 0924-9338. Resumen | Enlaces | BibTeX | Etiquetas: @article{Canal-Riveroa2018, title = {Predicting suicidal behaviour after first episode of non-affective psychosis: The role of neurocognitive functioning}, author = {Canal,M. and L\'{o}pez, J.D. and Seti\'{e}n, E. and Ruiz, M. and Ayuso-Mateos, J.L. and Ayesa, R. and Crespo-Facorroa,B.}, url = {https://doi.org/10.1016/j.eurpsy.2018.06.001}, isbn = {0924-9338}, year = {2018}, date = {2018-09-01}, journal = {European Psychiatry}, volume = {53}, pages = {52-57}, abstract = {Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period. Methods The sample of the study is composed by 517 patients. Sociodemographic, clinical, functional and neurocognitive measures were evaluated at baseline as well as 1-year and 3 years after first episode of psychosis. Bivariate and multivariate analyses explored the influence of these variables as putative baseline predictors of SB. Repeated measures analyses of variance tested differences in clinical and neurocognitive outcomes at 1- and 3-year follow-up. Results Global cognitive functioning (GCF) (OR = 1.83, 95% CI = 1.25\textendash2.67) and severe depressive symptoms (OR = 1.17, 95% CI = 1.07\textendash1.28) predicted SB. Longitudinal analyses revealed that patients with SB at follow-up presented with higher levels of remission in terms of positive psychotic symptoms and depression. In addition, those with a history of SB had worse GCF and visual memory than those without such antecedents. Conclusions GCF was found to be the most robust predictor of SB along with severe depressive symptomatology. Hence, poorer cognitive performance in FEP appears to emerge as a risk factor for suicidal behaviour from early stages of the illness and a comprehensive neurocognitive assessment may contribute to risk assessment}, keywords = {}, pubstate = {forthcoming}, tppubtype = {article} } Suicide has been recognised as one of the major causes of premature death in psychosis. However, predicting suicidal behaviour (SB) is still challenging in the clinical setting and the association of neurocognition with SB in psychosis remains poorly understood. This study aimed to investigate the role of neurocognitive performance as predictor of SB. Also, we sought to explore differences in the evolution of clinical and neurocognitive functioning between participants with/without history of suicide attempts (SA) over follow-up period. Methods The sample of the study is composed by 517 patients. Sociodemographic, clinical, functional and neurocognitive measures were evaluated at baseline as well as 1-year and 3 years after first episode of psychosis. Bivariate and multivariate analyses explored the influence of these variables as putative baseline predictors of SB. Repeated measures analyses of variance tested differences in clinical and neurocognitive outcomes at 1- and 3-year follow-up. Results Global cognitive functioning (GCF) (OR = 1.83, 95% CI = 1.25–2.67) and severe depressive symptoms (OR = 1.17, 95% CI = 1.07–1.28) predicted SB. Longitudinal analyses revealed that patients with SB at follow-up presented with higher levels of remission in terms of positive psychotic symptoms and depression. In addition, those with a history of SB had worse GCF and visual memory than those without such antecedents. Conclusions GCF was found to be the most robust predictor of SB along with severe depressive symptomatology. Hence, poorer cognitive performance in FEP appears to emerge as a risk factor for suicidal behaviour from early stages of the illness and a comprehensive neurocognitive assessment may contribute to risk assessment |
Pitkanen, T; Levola, J M; de la Fuente, J; Cabello, M Identifying psychosocial difficulties of inpatients with substance use disorders: evaluation of the usefulness of the PARADISE24 for clinical practise Artículo de revista Disabil Rehabil, (5), pp. 1–7, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30183423, title = {Identifying psychosocial difficulties of inpatients with substance use disorders: evaluation of the usefulness of the PARADISE24 for clinical practise}, author = {T Pitkanen and J M Levola and J de la Fuente and M Cabello}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Identifying+psychosocial++difficulties+of+inpatients+with+substance+use+disorders%3A+evaluation+of+the++usefulness+of+the+PARADISE24+for+clinical+practise.}, doi = {10.1080/09638288.2018.1493543}, year = {2018}, date = {2018-09-01}, journal = {Disabil Rehabil}, number = {5}, pages = {1--7}, abstract = {Improvements in overall functioning and well-being are important goals in the treatment of substance use disorders. The aim of the current study was to evaluate the usefulness of the PARADISE24 instrument for studying the scope and severity of psychosocial difficulties by comparing the results with other measures in the context of substance use disorders. This cross-sectional study included two independent inpatient samples. The first sample consisted of 80 interviews including the PARADISE24 and 10 other measures. The second sample consisted of the responses of 1082 inpatients to a self-administered PARADISE24 questionnaire. Inpatients with substance use disorders had experienced a wide range of psychosocial difficulties and the two samples produced similar results. Highest scores were observed for emotional difficulties. The PARADISE24 showed convergent validity with measures of disability and depressive symptoms and discriminant validity with personality traits and environmental factors (i.e., social support and caretaker's empathy). Psychosocial difficulties were inversely associated with quality of life and self-assessed health. The PARADISE24 provides a wide range of useful information on psychosocial difficulties for clinical work and it can be used as a self-administered questionnaire in the evaluation and treatment of substance use disorders. Implications for rehabilitation Individuals undergoing inpatient treatment for substance use disorders experience various and severe psychosocial difficulties. The PARADISE24 is an evidence-based instrument for assessing the scope and severity of 24 common psychosocial difficulties among neurological and psychiatric disorders. The PARADISE24 also offers a time-efficient method which can be used as a self-administered questionnaire in the context of substance use disorders. Comparison between the PARADISE24 and 10 commonly used measures showed that the PARADISE24 covered a wide variety of clinically relevant issues in one questionnaire.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Improvements in overall functioning and well-being are important goals in the treatment of substance use disorders. The aim of the current study was to evaluate the usefulness of the PARADISE24 instrument for studying the scope and severity of psychosocial difficulties by comparing the results with other measures in the context of substance use disorders. This cross-sectional study included two independent inpatient samples. The first sample consisted of 80 interviews including the PARADISE24 and 10 other measures. The second sample consisted of the responses of 1082 inpatients to a self-administered PARADISE24 questionnaire. Inpatients with substance use disorders had experienced a wide range of psychosocial difficulties and the two samples produced similar results. Highest scores were observed for emotional difficulties. The PARADISE24 showed convergent validity with measures of disability and depressive symptoms and discriminant validity with personality traits and environmental factors (i.e., social support and caretaker's empathy). Psychosocial difficulties were inversely associated with quality of life and self-assessed health. The PARADISE24 provides a wide range of useful information on psychosocial difficulties for clinical work and it can be used as a self-administered questionnaire in the evaluation and treatment of substance use disorders. Implications for rehabilitation Individuals undergoing inpatient treatment for substance use disorders experience various and severe psychosocial difficulties. The PARADISE24 is an evidence-based instrument for assessing the scope and severity of 24 common psychosocial difficulties among neurological and psychiatric disorders. The PARADISE24 also offers a time-efficient method which can be used as a self-administered questionnaire in the context of substance use disorders. Comparison between the PARADISE24 and 10 commonly used measures showed that the PARADISE24 covered a wide variety of clinically relevant issues in one questionnaire. |
Olaya, B; Moneta, M V; Miret, M; Ayuso-Mateos, J L; Haro, J M Epidemiology of panic attacks, panic disorder and the moderating role of age: Results from a population-based study Artículo de revista Journal of Affective Disorders, 241 , pp. 627-633, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{olaya2018epidemiology, title = {Epidemiology of panic attacks, panic disorder and the moderating role of age: Results from a population-based study}, author = {Olaya, B and Moneta, M.V and Miret, M and Ayuso-Mateos, J.L and Haro, J. M.}, doi = {https://doi.org/10.1016/j.jad.2018.08.069}, year = {2018}, date = {2018-08-16}, journal = {Journal of Affective Disorders}, volume = {241}, pages = {627-633}, publisher = {Elsevier}, abstract = {Background The aim of this study was to investigate the prevalence of panic attacks (PA) and panic disorder (PD) over the lifespan, determine the main correlates and analyze the potential moderating role of age Method We analyzed cross-sectional data from a nationally-representative sample of 4,569 non-institutionalized adults. Three panic groups were created according to results in the CIDI interview: non-panic, PA (without PD) and PD. Panic groups were used as outcomes in adjusted multinomial regression models where several correlates were investigated. Interactions between each covariate and age were explored Results The highest prevalence rates of PA (9.5%) and PD (3.3%) were found in people aged 30\textendash39 and 40\textendash49, respectively. Respondents aged 80 + presented the lowest rates. In the adjusted multinomial model, younger ages, having depression, and poorer levels of quality of life were significant correlates for both PA and PD, whereas being female and having 2 or more chronic conditions were only significant for PA (not for PD) and being a frequent drinker (last 12-months) only for PD. Age significantly interacted with frequent alcohol consumption in the last 12-months for PD. The predicted probability of having PD decreased with age for life-abstainer or occasional drinkers, whereas the probability increased with older ages for frequent drinkers. Limitations Low prevalence of PA and PD resulted in large confidence intervals whereas self-reports could be affected by recall bias. Conclusions Overall, our results suggest that the probability of having PA and PD decreases as people age and that the significant risk factors are independent of age. However, older adults with a frequent drink pattern seem to be at higher risk of PD. Future longitudinal studies are needed to determine the trajectories of PD and alcohol consumption over the lifespan.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background The aim of this study was to investigate the prevalence of panic attacks (PA) and panic disorder (PD) over the lifespan, determine the main correlates and analyze the potential moderating role of age Method We analyzed cross-sectional data from a nationally-representative sample of 4,569 non-institutionalized adults. Three panic groups were created according to results in the CIDI interview: non-panic, PA (without PD) and PD. Panic groups were used as outcomes in adjusted multinomial regression models where several correlates were investigated. Interactions between each covariate and age were explored Results The highest prevalence rates of PA (9.5%) and PD (3.3%) were found in people aged 30–39 and 40–49, respectively. Respondents aged 80 + presented the lowest rates. In the adjusted multinomial model, younger ages, having depression, and poorer levels of quality of life were significant correlates for both PA and PD, whereas being female and having 2 or more chronic conditions were only significant for PA (not for PD) and being a frequent drinker (last 12-months) only for PD. Age significantly interacted with frequent alcohol consumption in the last 12-months for PD. The predicted probability of having PD decreased with age for life-abstainer or occasional drinkers, whereas the probability increased with older ages for frequent drinkers. Limitations Low prevalence of PA and PD resulted in large confidence intervals whereas self-reports could be affected by recall bias. Conclusions Overall, our results suggest that the probability of having PA and PD decreases as people age and that the significant risk factors are independent of age. However, older adults with a frequent drink pattern seem to be at higher risk of PD. Future longitudinal studies are needed to determine the trajectories of PD and alcohol consumption over the lifespan. |
Domenech-Abella, J; Mundó, J; Leonardi, M; Chatterji, S; Tobiasz-Adamczyk, B; Koskinen, S; Ayuso-Mateos, J L; Haro, J M The association between socio-economic status and depression among older adults in Finland, Poland and Spain: a comparative cross-sectional study of distinct measures and pathways Artículo de revista Journal of Affective Disorders, 15 (241), pp. 311-318, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{domenech2018association, title = {The association between socio-economic status and depression among older adults in Finland, Poland and Spain: a comparative cross-sectional study of distinct measures and pathways}, author = {Domenech-Abella, J and Mund\'{o}, J and Leonardi, M and Chatterji, S and Tobiasz-Adamczyk, B and Koskinen, S and Ayuso-Mateos, J.L and Haro, J. M.}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=The+association+between+socioeconomic+status+and+depression+among+older+adults+in+Finland%2C+Poland+and+Spain%3A+A+comparative+cross-sectional+study+of+distinct+measures+and+pathways}, doi = {0.1016/j.jad.2018.08.077}, year = {2018}, date = {2018-08-15}, journal = {Journal of Affective Disorders}, volume = {15}, number = {241}, pages = {311-318}, publisher = {Elsevier}, abstract = {Background Socioeconomic status, as measured by education, occupation or income, is associated with depression. However, data are lacking on the psychosocial, material and behavioral mediators of these associations. We have examined the association of education, occupation and income with depression and the potential mediations using community-based data. Methods A total of 7,966 older adults were interviewed in Finland, Poland and Spain. The differential associations between depression and SES, mediator variables, country of residence and cofounder variables, such as chronic physical conditions, were assessed through logistic regression models. Meditation analyses were carried out using khb method for Stata 13.1. Results Education, followed by household income, were the SES indicators most frequently significantly associated with depression. These SES markers, but not occupation, showed an independent effect in this association. Psychosocial factors and loneliness in particular showed the strongest associations with depression among mediator variables. However, material factors and, especially, financial strain had a higher mediating function in the association between SES and depression. Overall, SES markers, chronic conditions and mediation factors were more positive in Finland than in Poland and Spain. Conclusion Improving psychosocial and material dimensions as well as access to the educational system for older adults might result in a reduction in the prevalence of depression in the general population and particularly among individuals with low SES.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background Socioeconomic status, as measured by education, occupation or income, is associated with depression. However, data are lacking on the psychosocial, material and behavioral mediators of these associations. We have examined the association of education, occupation and income with depression and the potential mediations using community-based data. Methods A total of 7,966 older adults were interviewed in Finland, Poland and Spain. The differential associations between depression and SES, mediator variables, country of residence and cofounder variables, such as chronic physical conditions, were assessed through logistic regression models. Meditation analyses were carried out using khb method for Stata 13.1. Results Education, followed by household income, were the SES indicators most frequently significantly associated with depression. These SES markers, but not occupation, showed an independent effect in this association. Psychosocial factors and loneliness in particular showed the strongest associations with depression among mediator variables. However, material factors and, especially, financial strain had a higher mediating function in the association between SES and depression. Overall, SES markers, chronic conditions and mediation factors were more positive in Finland than in Poland and Spain. Conclusion Improving psychosocial and material dimensions as well as access to the educational system for older adults might result in a reduction in the prevalence of depression in the general population and particularly among individuals with low SES. |
Ávila, C; Ayuso-Mateos, J L; Muñoz-Murillo, A; Scaratti, C; Coenen, M; Vlachou, A; Fheodoroff, K; Pilat, A; Tabaj, A; Svestkova, O; Kadyrbaeva, A; Cabello, M Identifying the Employment Needs of People with Chronic Ħealth Conditions in Europe Artículo de revista J. Occup. Environ. Med., 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid30095532, title = {Identifying the Employment Needs of People with Chronic {H}ealth Conditions in Europe}, author = {\'{A}vila, C and Ayuso-Mateos, J.L and Mu\~{n}oz-Murillo, A and Scaratti, C and Coenen, M and Vlachou, A and Fheodoroff, K and Pilat, A and Tabaj, A and Svestkova, O and Kadyrbaeva, A and Cabello, M.}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Identifying+the+Employment+Needs+of+People+with+Chronic+Health+Conditions+in+Europe.}, doi = {10.1097/JOM.0000000000001425}, year = {2018}, date = {2018-08-01}, journal = {J. Occup. Environ. Med.}, abstract = {The main goal of this study was to compare the employment needs experienced by people with different chronic health conditions and in different welfare systems. A total of 688 participants with six chronic health conditions were collected in ninecountries representing four welfare systems in Europe (Continental, Mediterranean, Post-communist and Scandinavian). Raisingawareness of what is to live with a chronic health condition in the workplace was the area perceived as more favorable. The types of employment needs were different across the social welfare systems but did not vary among the different chronic health conditions groups. Although diverse, there appear to be some common needs transversal to the working experience of people with chronic health problems. Actions to improve the employability of people with chronic health conditions should be tailored to each welfare system.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The main goal of this study was to compare the employment needs experienced by people with different chronic health conditions and in different welfare systems. A total of 688 participants with six chronic health conditions were collected in ninecountries representing four welfare systems in Europe (Continental, Mediterranean, Post-communist and Scandinavian). Raisingawareness of what is to live with a chronic health condition in the workplace was the area perceived as more favorable. The types of employment needs were different across the social welfare systems but did not vary among the different chronic health conditions groups. Although diverse, there appear to be some common needs transversal to the working experience of people with chronic health problems. Actions to improve the employability of people with chronic health conditions should be tailored to each welfare system. |
Vancampfort, D; Stubbs, B; Lara, E; Vandenbulcke, M; Swinnen, N; Smith, L; Firth, J; Herring, M P; Hallgren, M; Koyanagi, A Mild cognitive impairment and sedentary behavior: A multinational study Artículo de revista Experimental Gerontology, 108 , pp. 174-180, 2018, ISSN: 0531-5565. Resumen | Enlaces | BibTeX | Etiquetas: @article{Vancampfort2018, title = {Mild cognitive impairment and sedentary behavior: A multinational study}, author = {Vancampfort, D and Stubbs, B and Lara, E and Vandenbulcke, M and Swinnen, N and Smith, L and Firth, J and Herring, M.P and Hallgren, M and Koyanagi, A. }, url = {https://www.ncbi.nlm.nih.gov/pubmed/29704638}, issn = {0531-5565}, year = {2018}, date = {2018-07-15}, journal = {Experimental Gerontology}, volume = {108}, pages = {174-180}, abstract = {AbstractBackground Sedentary behavior (SB) is associated with poor cognitive performance. However, the contribution of sedentary time to risk of mild cognitive impairment (MCI) remains unclear. This study assessed the association of SB with MCI in six low- and middle-income countries. Methods The Study on Global Ageing and Adult Health (SAGE) survey included 34,129 adults aged >=50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. SB was self-reported and expressed as a categorical variable [<8 or >=8 h per day (high SB)]. The definition of MCI was based on the recommendations of the National Institute on Ageing-Alzheimer's Association. Multivariable logistic regression analysis was conducted to assess the association between SB and MCI. Results The overall prevalence (95%CI) of MCI and high SB (i.e., >=8 h/day) were 15.3% (14.4%-16.3%) and 10.1% (9.0%-11.3%), respectively. After adjustment for potential confounders, being sedentary for >=8 h/day was associated with a 1.56 (95%CI = 1.27-1.91) times higher odds for MCI. A one-hour increase in SB was associated with a 1.08 (95%CI = 1.05-1.11) times higher odds for MCI. Conclusion Our study results highlight the need to further explore a sedentary lifestyle as a potential risk factor for MCI or subsequent dementia. Longitudinal and intervention studies are warranted to confirm/refute the current findings.}, keywords = {}, pubstate = {published}, tppubtype = {article} } AbstractBackground Sedentary behavior (SB) is associated with poor cognitive performance. However, the contribution of sedentary time to risk of mild cognitive impairment (MCI) remains unclear. This study assessed the association of SB with MCI in six low- and middle-income countries. Methods The Study on Global Ageing and Adult Health (SAGE) survey included 34,129 adults aged >=50 years [mean (SD) age 62.1 (15.6) years; 51.7% females]. SB was self-reported and expressed as a categorical variable [<8 or >=8 h per day (high SB)]. The definition of MCI was based on the recommendations of the National Institute on Ageing-Alzheimer's Association. Multivariable logistic regression analysis was conducted to assess the association between SB and MCI. Results The overall prevalence (95%CI) of MCI and high SB (i.e., >=8 h/day) were 15.3% (14.4%-16.3%) and 10.1% (9.0%-11.3%), respectively. After adjustment for potential confounders, being sedentary for >=8 h/day was associated with a 1.56 (95%CI = 1.27-1.91) times higher odds for MCI. A one-hour increase in SB was associated with a 1.08 (95%CI = 1.05-1.11) times higher odds for MCI. Conclusion Our study results highlight the need to further explore a sedentary lifestyle as a potential risk factor for MCI or subsequent dementia. Longitudinal and intervention studies are warranted to confirm/refute the current findings. |
Reed, G M; Keeley, J W; Rebello, T J; First, M B; Gureje, O; Ayuso-Mateos, J L; Kanba, S; Khoury, B; Kogan, C S; Krasnov, V N; Maj, M; de Mari, Jesus J; Sharan, P; Stein, D J; Zhao, M; Akiyama, T; Andrews, H F; Asevedo, E; Cheour, M; Domínguez-Martínez, T; El-Khoury, J; Fiorillo, A; Grenier, J; Gupta, N; Kola, L; Kulygina, M; Leal-Leturia, I; Luciano, M; Lusu, B; Nicolás, J; Martínez-López, I; Matsumoto, C; Odunleye, M; Onofa, Umukoro L; Paterniti, S; Purnima, S; Robles, R; Sahu, M K; Sibeko, G; Zhong, N; Gaebel, W; Lovell, A M; Maruta, T; K M Pike and, Roberts M C; Medina-Mora, M E The ICD-11 developmental field study of reliability of diagnoses of high-burden mental disorders: results among adult patients in mental health settings of 13 countries Artículo de revista World Psychiatry, 17 (2), pp. 174-186, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{Reed12018b, title = {The ICD-11 developmental field study of reliability of diagnoses of high-burden mental disorders: results among adult patients in mental health settings of 13 countries}, author = {G M Reed and J W Keeley and T J Rebello and M B. First and O Gureje and J L Ayuso-Mateos and S Kanba and B Khoury and C S Kogan and V N Krasnov and M Maj and J de Jesus Mari and P Sharan and D J Stein and M Zhao and T Akiyama and H F Andrews and E Asevedo and M Cheour and T Dom\'{i}nguez-Mart\'{i}nez and J El-Khoury and A Fiorillo and J Grenier and N Gupta and L Kola and M Kulygina and I Leal-Leturia and M Luciano and B Lusu and J. Nicol\'{a}s and I. Mart\'{i}nez-L\'{o}pez and C Matsumoto and M Odunleye and L Umukoro Onofa and S Paterniti and S Purnima and R Robles and M K Sahu and G Sibeko and N Zhong and W Gaebel and A M Lovell and T Maruta and K M Pike and, M C Roberts and M E Medina-Mora}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29856568}, doi = {10.1002/wps.20524}, year = {2018}, date = {2018-07-01}, journal = {World Psychiatry}, volume = {17}, number = {2}, pages = {174-186}, abstract = {IReliable, clinically useful, and globally applicable diagnostic classification of mental disorders is an essential foundation for global mental health. The World Health Organization (WHO) is nearing completion of the 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11). The present study assessed inter-diagnostician reliability of mental disorders accounting for the greatest proportion of global disease burden and the highest levels of service utilization - schizophrenia and other primary psychotic disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically associated with stress - among adult patients presenting for treatment at 28 participating centers in 13 countries. A concurrent joint-rater design was used, focusing specifically on whether two clinicians, relying on the same clinical information, agreed on the diagnosis when separately applying the ICD-11 diagnostic guidelines. A total of 1,806 patients were assessed by 339 clinicians in the local language. Intraclass kappa coefficients for diagnoses weighted by site and study prevalence ranged from 0.45 (dysthymic disorder) to 0.88 (social anxiety disorder) and would be considered moderate to almost perfect for all diagnoses. Overall, the reliability of the ICD-11 diagnostic guidelines was superior to that previously reported for equivalent ICD-10 guidelines. These data provide support for the suitability of the ICD-11 diagnostic guidelines for implementation at a global level. The findings will inform further revision of the ICD-11 diagnostic guidelines prior to their publication and the development of programs to support professional training and implementation of the ICD-11 by WHO member states.}, keywords = {}, pubstate = {published}, tppubtype = {article} } IReliable, clinically useful, and globally applicable diagnostic classification of mental disorders is an essential foundation for global mental health. The World Health Organization (WHO) is nearing completion of the 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11). The present study assessed inter-diagnostician reliability of mental disorders accounting for the greatest proportion of global disease burden and the highest levels of service utilization - schizophrenia and other primary psychotic disorders, mood disorders, anxiety and fear-related disorders, and disorders specifically associated with stress - among adult patients presenting for treatment at 28 participating centers in 13 countries. A concurrent joint-rater design was used, focusing specifically on whether two clinicians, relying on the same clinical information, agreed on the diagnosis when separately applying the ICD-11 diagnostic guidelines. A total of 1,806 patients were assessed by 339 clinicians in the local language. Intraclass kappa coefficients for diagnoses weighted by site and study prevalence ranged from 0.45 (dysthymic disorder) to 0.88 (social anxiety disorder) and would be considered moderate to almost perfect for all diagnoses. Overall, the reliability of the ICD-11 diagnostic guidelines was superior to that previously reported for equivalent ICD-10 guidelines. These data provide support for the suitability of the ICD-11 diagnostic guidelines for implementation at a global level. The findings will inform further revision of the ICD-11 diagnostic guidelines prior to their publication and the development of programs to support professional training and implementation of the ICD-11 by WHO member states. |
Fiol-Veny, A; De La Torre-Luque, A; Balle, M; Bornas, X Altered Heart Rate Regulation in Adolescent Girls and the Vulnerability for Internalizing Disorders Artículo de revista Front Physiol., (9), 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{A12018, title = {Altered Heart Rate Regulation in Adolescent Girls and the Vulnerability for Internalizing Disorders}, author = {Fiol-Veny, A and De La Torre-Luque, A and Balle, M and Bornas, X.}, doi = {10.3389/fphys.2018.00852}, year = {2018}, date = {2018-07-01}, journal = {Front Physiol.}, number = {9}, abstract = {Background: The association between decreased heart rate variability (HRV) and increased internalizing symptoms is well documented. Adolescence is a critical period for the development of mental health problems, in particular internalizing symptoms. Previous research has illustrated sex differences in adolescent HRV, such that females have reduced short-term resting state HRV compared to males. Studies on long-term ecological recordings of HRV in adolescents are scarce. The aims of the present study were, (a) to test if adolescent females show decreased long-term HRV and cardiac complexity (CC) compared to males, and (b) to explore whether sex and HRV and CC measures, as well as their interaction, would predict internalizing symptoms. Materials and Methods: HRV was recorded in n = 166 adolescents (86 girls), on a normal school day. HRV and CC measures were calculated on the interbeat interval time series. Results: Females showed lower HRV and CC in most of the assessed indices. Internalizing symptoms were mainly predicted by HRV whereas sex only predicted symptoms of social anxiety. The interaction between sex and HRV did not predict internalizing symptoms. Conclusions: Results suggest that reduced HRV should be considered as a potential contributor to exacerbating internalizing symptoms in adolescence. Girls with reduced HRV and CC might be prone to the development of internalizing disorders. HRV is a promising tool for the early identification of vulnerability.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: The association between decreased heart rate variability (HRV) and increased internalizing symptoms is well documented. Adolescence is a critical period for the development of mental health problems, in particular internalizing symptoms. Previous research has illustrated sex differences in adolescent HRV, such that females have reduced short-term resting state HRV compared to males. Studies on long-term ecological recordings of HRV in adolescents are scarce. The aims of the present study were, (a) to test if adolescent females show decreased long-term HRV and cardiac complexity (CC) compared to males, and (b) to explore whether sex and HRV and CC measures, as well as their interaction, would predict internalizing symptoms. Materials and Methods: HRV was recorded in n = 166 adolescents (86 girls), on a normal school day. HRV and CC measures were calculated on the interbeat interval time series. Results: Females showed lower HRV and CC in most of the assessed indices. Internalizing symptoms were mainly predicted by HRV whereas sex only predicted symptoms of social anxiety. The interaction between sex and HRV did not predict internalizing symptoms. Conclusions: Results suggest that reduced HRV should be considered as a potential contributor to exacerbating internalizing symptoms in adolescence. Girls with reduced HRV and CC might be prone to the development of internalizing disorders. HRV is a promising tool for the early identification of vulnerability. |
van der Wee, N J A; Bilderbeck, A C; Cabello, M; Ayuso-Mateos, J L; Saris, I M J; Giltay, E J; Penninx, WJH B; Arango, C; Post, A; Porcelli, S Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer's disease Artículo de revista Neuroscience & Biobehavioral Reviews , 2018, ISSN: 0149-7634. Resumen | Enlaces | BibTeX | Etiquetas: @article{ref1d, title = {Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimer's disease}, author = {N J A van der Wee and A C Bilderbeck and M Cabello and J L Ayuso-Mateos and I M J Saris and E J Giltay and B WJH Penninx and C Arango and A Post and S Porcelli}, url = {https://www.sciencedirect.com/science/article/pii/S0149763417307583}, issn = {0149-7634}, year = {2018}, date = {2018-06-24}, journal = {Neuroscience & Biobehavioral Reviews }, abstract = {Abstract Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. In this paper, we discuss the working definition of social withdrawal for this study and the selection of objective and subjective rating scales to assess social withdrawal chosen or adapted for this project. We also discuss the MRI and EEG paradigms selected to study the systems and neural circuitry thought to underlie social functioning and more particularly to be involved in social withdrawal in humans, such as the social perception and the social affiliation networks. A number of behavioral paradigms were selected to assess complementary aspects of social cognition. Also, a digital phenotyping method (a smartphone application) was chosen to obtain real-life data.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Abstract Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. In this paper, we discuss the working definition of social withdrawal for this study and the selection of objective and subjective rating scales to assess social withdrawal chosen or adapted for this project. We also discuss the MRI and EEG paradigms selected to study the systems and neural circuitry thought to underlie social functioning and more particularly to be involved in social withdrawal in humans, such as the social perception and the social affiliation networks. A number of behavioral paradigms were selected to assess complementary aspects of social cognition. Also, a digital phenotyping method (a smartphone application) was chosen to obtain real-life data. |
Lara, E; Martín-María, N; Ådnanes, M; Amaddeo, F; Cresswell-Smith, J; Donisi, V; Forsman, A; Grigoletti, L; Halvorsen, T; Kalseth, J; Kaasbøll, J; Nyholm, L; Melby, L; Nordmyr, J; Rabbi, L; Wahlbeck, K; Miret, M Mental well-being and its determinants among the oldest old Artículo de revista Journal of Psychosomatic Research, 109 , pp. 113–114, 2018. @article{lara2018mental, title = {Mental well-being and its determinants among the oldest old}, author = {Lara, E and Mart\'{i}n-Mar\'{i}a, N and r{A}dnanes, M and Amaddeo, F and Cresswell-Smith, J and Donisi, V and Forsman, A and Grigoletti, L and Halvorsen, T and Kalseth, J and Kaasb\oll, J and Nyholm, L and Melby, L and Nordmyr, J and Rabbi, L and Wahlbeck, K and Miret, M.}, url = {https://www.jpsychores.com/article/S0022-3999(18)30295-2/abstract}, doi = { https://doi.org/10.1016/j.jpsychores.2018.03.086}, year = {2018}, date = {2018-06-01}, journal = {Journal of Psychosomatic Research}, volume = {109}, pages = {113--114}, publisher = {Elsevier}, keywords = {}, pubstate = {published}, tppubtype = {article} } |
Sanchez-Moreno, J; Bonnin, C M; Gonzalez-Pinto, A; Amann, B L; Sole, B; Balanza-Martinez, V; Arango, C; Jimenez, E; Tabares-Seisdedos, R; Garcia-Portilla, M P; Ibanez, A; Crespo, J M; Ayuso-Mateos, J L; Martinez-Aran, A; Torrent, C; Vieta, E; Alegria, A; Al-Halabi, S; Alonso-Lana, S; Anaya, C; Lopez, P; Bobes, J; Chiclana, G; Cerrillo, E; Correa, P; Custal, N; Fernandez, P; Garcia, S; Fuentes-Dura, I; Galvan, G; Gonzalez-Ortega, I; Isella, S; Landin-Romero, R; Menchon, M; Merchan-Naranjo, J; Ortiz-Gil, J; Pacchiarotti, I; Reyes, R; Rapado-Castro, M; Reinares, M; Rodao, M; Saiz, P A; Segura, B; Selva-Vera, G; Saiz-Ruiz, J; Soria, V; Zorrilla, I; Valle, J; Valls, E; Varo, C Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables Artículo de revista Acta Psychiatr Scand, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29726004, title = {Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables}, author = {J Sanchez-Moreno and C M Bonnin and A Gonzalez-Pinto and B L Amann and B Sole and V Balanza-Martinez and C Arango and E Jimenez and R Tabares-Seisdedos and M P Garcia-Portilla and A Ibanez and J M Crespo and J L Ayuso-Mateos and A Martinez-Aran and C Torrent and E Vieta and A Alegria and S Al-Halabi and S Alonso-Lana and C Anaya and P Lopez and J Bobes and G Chiclana and E Cerrillo and P Correa and N Custal and P Fernandez and S Garcia and I Fuentes-Dura and G Galvan and I Gonzalez-Ortega and S Isella and R Landin-Romero and M Menchon and J Merchan-Naranjo and J Ortiz-Gil and I Pacchiarotti and R Reyes and M Rapado-Castro and M Reinares and M Rodao and P A Saiz and B Segura and G Selva-Vera and J Saiz-Ruiz and V Soria and I Zorrilla and J Valle and E Valls and C Varo}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=Factors+associated+with+poor+functional+outcome+in+bipolar+disorder%3A+sociodemographic%2C+clinical%2C+and+neurocognitive+variables}, year = {2018}, date = {2018-05-03}, journal = {Acta Psychiatr Scand}, abstract = {The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD. |
Lopez-Garcia, P; Niendam, T A; Ashby, S; Pierce, K; Carter, C Aggression in First Episode Psychosis: Characteristics and Associated Factors Artículo de revista Biological Psychiatry, 83 (9), pp. S333–S334, 2018. @article{lopez2018f244, title = {Aggression in First Episode Psychosis: Characteristics and Associated Factors}, author = {Lopez-Garcia, P and Niendam, T.A and Ashby, S and Pierce, K and Carter, C}, year = {2018}, date = {2018-05-01}, journal = {Biological Psychiatry}, volume = {83}, number = {9}, pages = {S333--S334}, publisher = {Elsevier}, abstract = {Background: The early stages of psychosis are associated with high rates of aggression [1], with approximately one third of individuals committing an aggressive act prior to initiating treatment [2]. Aggression is not a unitary construct and can be defined in various ways (i.e. proactive and reactive aggression) with potentially distinct causal pathways. Rates of reactive aggression are much more common than proactive aggression in the early psychosis population, are among the most socially disruptive symptoms in this population, and may be the most amenable to intervention. Aggression in this population is associated with various clinical and demographic factors. Understanding etiology of aggression and contributing factors can guide development of targeted treatments. We aim to determine the rate of aggressive behavior in first episode psychosis patients, to characterize the type of aggression and to study the clinical characteristics associated with aggressive behavior. Methods: We have conducted a retrospective review of clinical charts to examine the rates of aggressive behaviors in 575 individuals who who presented for care for at the University of California, Davis Early Diagnosis and Preventive Treatment (EDAPT) Clinic, an outpatient early psychosis clinic. Eligibility as FEP (first episode psychosis) or CHR (clinical high risk) was determined through the SIPS, SCID-IV and K-SADS. Presence and type of aggression was based on patient and/or collateral report of past month aggressive behavior on the Modified Overt Aggression Scale. Presence of birth complications, developmental and learning problems and comorbid diagnosis were rated based upon information gathered from retrospective chart review. Results: We examined the rates of aggressive behaviors in 450 first episode psychosis and 125 clinical high risk individuals. Fiftysix percent (n = 320) reported a history of aggressive behavior, 54% of FEP and 61% of CHR. Of the total sample, 50% showed aggression toward others, 18% aggression towards self and others, and 8% aggression towards objects only. Aggressive behavior was predominantly physical (53%), although many individuals also demonstrated both physical and verbal aggression (32%). Proactive aggressive behavior was shown in 33.3% while reactive aggressive behavior was shown in 61.1%. The duration of untreated psychosis was longer in non-aggressive subjects. Aggressive behavior was associated with learningproblems (p = 0.001) and developmental delay (p = 0.05). Birth complications and a history of neurological conditions were associated with aggressive behavior. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Background: The early stages of psychosis are associated with high rates of aggression [1], with approximately one third of individuals committing an aggressive act prior to initiating treatment [2]. Aggression is not a unitary construct and can be defined in various ways (i.e. proactive and reactive aggression) with potentially distinct causal pathways. Rates of reactive aggression are much more common than proactive aggression in the early psychosis population, are among the most socially disruptive symptoms in this population, and may be the most amenable to intervention. Aggression in this population is associated with various clinical and demographic factors. Understanding etiology of aggression and contributing factors can guide development of targeted treatments. We aim to determine the rate of aggressive behavior in first episode psychosis patients, to characterize the type of aggression and to study the clinical characteristics associated with aggressive behavior. Methods: We have conducted a retrospective review of clinical charts to examine the rates of aggressive behaviors in 575 individuals who who presented for care for at the University of California, Davis Early Diagnosis and Preventive Treatment (EDAPT) Clinic, an outpatient early psychosis clinic. Eligibility as FEP (first episode psychosis) or CHR (clinical high risk) was determined through the SIPS, SCID-IV and K-SADS. Presence and type of aggression was based on patient and/or collateral report of past month aggressive behavior on the Modified Overt Aggression Scale. Presence of birth complications, developmental and learning problems and comorbid diagnosis were rated based upon information gathered from retrospective chart review. Results: We examined the rates of aggressive behaviors in 450 first episode psychosis and 125 clinical high risk individuals. Fiftysix percent (n = 320) reported a history of aggressive behavior, 54% of FEP and 61% of CHR. Of the total sample, 50% showed aggression toward others, 18% aggression towards self and others, and 8% aggression towards objects only. Aggressive behavior was predominantly physical (53%), although many individuals also demonstrated both physical and verbal aggression (32%). Proactive aggressive behavior was shown in 33.3% while reactive aggressive behavior was shown in 61.1%. The duration of untreated psychosis was longer in non-aggressive subjects. Aggressive behavior was associated with learningproblems (p = 0.001) and developmental delay (p = 0.05). Birth complications and a history of neurological conditions were associated with aggressive behavior. |
J.L, Ayuso-Mateos The process of preparing the chapter on mental and behavioural disorders of the ICD 11 Artículo de revista Rev Psiquiatr Salud Ment, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29699881, title = {The process of preparing the chapter on mental and behavioural disorders of the ICD 11}, author = {Ayuso-Mateos J.L}, url = {https://www.ncbi.nlm.nih.gov/pubmed/?term=El+proceso+de+preparaci%C3%B3n+del+cap%C3%ADtulo+de+Trastornos+mentales+y+del+comportamiento+de+la+CIE+11}, year = {2018}, date = {2018-04-23}, journal = {Rev Psiquiatr Salud Ment}, abstract = {La d\'{e}cima edici\'{o}n de la Clasificaci\'{o}n internacional de enfermedades y los problemas de salud relacionados (CIE) es en la actualidad el est\'{a}ndar internacional para recoger informaci\'{o}n sobre las enfermedades. Los pa\'{i}ses miembros de la Organizaci\'{o}n Mundial de la Salud (OMS) han acordado utilizar la CIE como referente para recoger y transmitir la informaci\'{o}n sobre las enfermedades con muy diferentes objetivos; en primer t\'{e}rmino, para monitorizar las epidemias, las amenazas a la salud p\'{u}blica y analizar la carga de enfermedad, en segundo lugar para evaluar el progreso en el cumplimiento de los objetivos de salud p\'{u}blica, y tambi\'{e}n se utiliza para definir las obligaciones de los estados miembros de la OMS en relaci\'{o}n con la provisi\'{o}n de servicios de salud gratuitos o subsidiados a su poblaci\'{o}n, siendo un instrumento clave para facilitar el acceso a los servicios de salud }, keywords = {}, pubstate = {published}, tppubtype = {article} } La décima edición de la Clasificación internacional de enfermedades y los problemas de salud relacionados (CIE) es en la actualidad el estándar internacional para recoger información sobre las enfermedades. Los países miembros de la Organización Mundial de la Salud (OMS) han acordado utilizar la CIE como referente para recoger y transmitir la información sobre las enfermedades con muy diferentes objetivos; en primer término, para monitorizar las epidemias, las amenazas a la salud pública y analizar la carga de enfermedad, en segundo lugar para evaluar el progreso en el cumplimiento de los objetivos de salud pública, y también se utiliza para definir las obligaciones de los estados miembros de la OMS en relación con la provisión de servicios de salud gratuitos o subsidiados a su población, siendo un instrumento clave para facilitar el acceso a los servicios de salud |
Santos, D; Abad, F J; Miret, M; Chatterji, S; Olaya, B; Zawisza, K; Koskinen, S; Leonardi, M; Haro, J M; Ayuso-Mateos, J L; Caballero, F F Measurement invariance of the WHOQOL-AGE questionnaire across three European countries Artículo de revista Qual Life Res, 27 (4), pp. 1015–1025, 2018. @article{pmid29143905, title = {Measurement invariance of the WHOQOL-AGE questionnaire across three European countries}, author = {D Santos and F J Abad and M Miret and S Chatterji and B Olaya and K Zawisza and S Koskinen and M Leonardi and J M Haro and J L Ayuso-Mateos and F F Caballero}, year = {2018}, date = {2018-04-01}, journal = {Qual Life Res}, volume = {27}, number = {4}, pages = {1015--1025}, abstract = {Developing valid and reliable instruments that can be used across countries is necessary. The present study aimed to test the comparability of quality of life scores across three European countries (Finland, Poland, and Spain). Data from 9987 participants interviewed between 2011 and 2012 were employed, using nationally representative samples from the Collaborative Research on Ageing in Europe project. The WHOQOL-AGE questionnaire is a 13-item test and was employed to assess the quality of life in the three considered countries. First of all, two models (a bifactor model and a two-correlated factor model) were proposed and tested in each country by means of confirmatory factor models. Second, measurement invariance across the three countries was tested using multi-group confirmatory factor analysis for that model which showed the best fit. Finally, differences in latent mean scores across countries were analyzed. The results indicated that the bifactor model showed more satisfactory goodness-of-fit indices than the two-correlated factor model and that the WHOQOL-AGE questionnaire is a partially scalar invariant instrument (only two items do not meet scalar invariance). Quality of life scores were higher in Finland (considered as the reference category: mean = 0}, keywords = {}, pubstate = {published}, tppubtype = {article} } Developing valid and reliable instruments that can be used across countries is necessary. The present study aimed to test the comparability of quality of life scores across three European countries (Finland, Poland, and Spain). Data from 9987 participants interviewed between 2011 and 2012 were employed, using nationally representative samples from the Collaborative Research on Ageing in Europe project. The WHOQOL-AGE questionnaire is a 13-item test and was employed to assess the quality of life in the three considered countries. First of all, two models (a bifactor model and a two-correlated factor model) were proposed and tested in each country by means of confirmatory factor models. Second, measurement invariance across the three countries was tested using multi-group confirmatory factor analysis for that model which showed the best fit. Finally, differences in latent mean scores across countries were analyzed. The results indicated that the bifactor model showed more satisfactory goodness-of-fit indices than the two-correlated factor model and that the WHOQOL-AGE questionnaire is a partially scalar invariant instrument (only two items do not meet scalar invariance). Quality of life scores were higher in Finland (considered as the reference category: mean = 0 |
de la Fuente, J; Cabello, M; Levola, J; Caballero, F F; Ayuso-Mateos, J L; Pitkänen, T Validity of the PARADISE24 questionnaire in people with substance use disorders: A measure to assess psychosocial difficulties Artículo de revista Drug & Alcohol Dependence, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{de2018validity, title = {Validity of the PARADISE24 questionnaire in people with substance use disorders: A measure to assess psychosocial difficulties}, author = {J de la Fuente and M Cabello and J Levola and F F Caballero and J L Ayuso-Mateos and T Pitk\"{a}nen}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29627408}, year = {2018}, date = {2018-03-27}, journal = {Drug & Alcohol Dependence}, publisher = {Elsevier}, abstract = {Psychosocial difficulties (PSDs) are common in people with substance use disorders (SUDs). The PARADISE24 has been shown to be an adequate tool for measuring PSDs in inpatients with SUDs. The aim of this study is to evaluate the psychometric properties of the PARADISE24 in a sample of patients with SUDs. 2637 participants with SUDs completed the PARADISE24 questionnaire during their treatment. The latent structure of the PARADISE24 questionnaire was analyzed in the outpatient sample by means of exploratory and confirmatory factor analysis (EFA and CFA). Metric invariance was then assessed in relation to the inpatient sample using multiple group CFA. Finally, evidences of known-groups validity were checked to test the ability of the questionnaire to differentiate between socio-demographic and clinical groups. The one-factor model presented an adequate fit in both the EFA (CFI = 0.98; TLI = 0.98; RMSEA = 0.07) and the CFA (CFI = 0.98; TLI = 0.98; RMSEA = 0.07) solutions. The reliability of the scale was found to be high (α = 0.93). Strict metric invariance between inpatients and outpatients was achieved (RMSEA = 0.063; TLI = 0.983; CFI = 0.981). The PARADISE24 was able to discriminate between the inpatients and outpatients at both latent (d = 0.98) and observed levels (d = 0.86). The PARADISE24 is a unidimensional tool that is reliable for assessing and comparing PSDs in both outpatients and inpatients with SUDs. Further research is required for evaluating the ability of the PARADISE24 to quantify longitudinal changes in PSDs. }, keywords = {}, pubstate = {published}, tppubtype = {article} } Psychosocial difficulties (PSDs) are common in people with substance use disorders (SUDs). The PARADISE24 has been shown to be an adequate tool for measuring PSDs in inpatients with SUDs. The aim of this study is to evaluate the psychometric properties of the PARADISE24 in a sample of patients with SUDs. 2637 participants with SUDs completed the PARADISE24 questionnaire during their treatment. The latent structure of the PARADISE24 questionnaire was analyzed in the outpatient sample by means of exploratory and confirmatory factor analysis (EFA and CFA). Metric invariance was then assessed in relation to the inpatient sample using multiple group CFA. Finally, evidences of known-groups validity were checked to test the ability of the questionnaire to differentiate between socio-demographic and clinical groups. The one-factor model presented an adequate fit in both the EFA (CFI = 0.98; TLI = 0.98; RMSEA = 0.07) and the CFA (CFI = 0.98; TLI = 0.98; RMSEA = 0.07) solutions. The reliability of the scale was found to be high (α = 0.93). Strict metric invariance between inpatients and outpatients was achieved (RMSEA = 0.063; TLI = 0.983; CFI = 0.981). The PARADISE24 was able to discriminate between the inpatients and outpatients at both latent (d = 0.98) and observed levels (d = 0.86). The PARADISE24 is a unidimensional tool that is reliable for assessing and comparing PSDs in both outpatients and inpatients with SUDs. Further research is required for evaluating the ability of the PARADISE24 to quantify longitudinal changes in PSDs. |
Foitzek, N; Ávila, C; Ivandic, I; Bitenc, C; Cabello, M; Gruber, S; Leonardi, M; Muñoz-Murillo, A; Scaratti, C; Tobiasz-Adamczyk, B; Vlachou, A; Esteban, E; Sabariego, C; Coenen, M What Persons with Chronic Health Conditions Need to Maintain or Return to Work-Results of an Online-Survey in Seven European Countries Artículo de revista Int J Environ Res Public Health, 15 (4), 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29587433, title = {What Persons with Chronic Health Conditions Need to Maintain or Return to Work-Results of an Online-Survey in Seven European Countries}, author = {Foitzek, N and \'{A}vila, C and Ivandic, I and Bitenc, C and Cabello, M and Gruber, S and Leonardi, M and Mu\~{n}oz-Murillo, A and Scaratti, C and Tobiasz-Adamczyk, B and Vlachou, A and Esteban, E and Sabariego, C and Coenen, M}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29587433}, year = {2018}, date = {2018-03-26}, journal = {Int J Environ Res Public Health}, volume = {15}, number = {4}, abstract = {Chronic health conditions represent the major share of the disease burden in Europe and have a significant impact on work. This study aims to: (1) identify factors that have a negative or positive impact on the work lives of persons with chronic health conditions; (2) explore the needs of these persons to maintain a job or return to work and (3) compare these results with respect to these persons' occupational status. An online survey was performed in seven European countries. Open-ended survey questions were analyzed using qualitative methods. In total, 487 participants with six chronic health conditions participated. The majority of participants named work-related aspects (such as career development, stress at the workplace, work structure and schedule as well as workload), support of others and attitudes of others as being the factors positively and negatively impact their work lives the most. Our study shed light on the importance of changing the attitudes of supervisors and co-workers to counteract stigmatization of persons with chronic health conditions in the workplace. In conclusion, this study provides a basis for developing new strategies of integration and reintegration at work for persons with chronic health conditions in European countries.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Chronic health conditions represent the major share of the disease burden in Europe and have a significant impact on work. This study aims to: (1) identify factors that have a negative or positive impact on the work lives of persons with chronic health conditions; (2) explore the needs of these persons to maintain a job or return to work and (3) compare these results with respect to these persons' occupational status. An online survey was performed in seven European countries. Open-ended survey questions were analyzed using qualitative methods. In total, 487 participants with six chronic health conditions participated. The majority of participants named work-related aspects (such as career development, stress at the workplace, work structure and schedule as well as workload), support of others and attitudes of others as being the factors positively and negatively impact their work lives the most. Our study shed light on the importance of changing the attitudes of supervisors and co-workers to counteract stigmatization of persons with chronic health conditions in the workplace. In conclusion, this study provides a basis for developing new strategies of integration and reintegration at work for persons with chronic health conditions in European countries. |
Vancampfort, D; Lara, E; Stubbs, B; Swinnen, N; Probst, M; Koyanagi, A Physical activity correlates in people with mild cognitive impairment: findings from six low- and middle-income countries Artículo de revista Public Health, 156 , pp. 15-25, 2018, ISSN: 0033-3506. Resumen | Enlaces | BibTeX | Etiquetas: @article{ref1c, title = {Physical activity correlates in people with mild cognitive impairment: findings from six low- and middle-income countries}, author = {D Vancampfort and E Lara and B Stubbs and N Swinnen and M Probst and A Koyanagi}, url = {http://dx.doi.org/10.1016/j.puhe.2017.12.002}, doi = {10.1016/j.puhe.2017.12.002}, issn = {0033-3506}, year = {2018}, date = {2018-03-01}, journal = {Public Health}, volume = {156}, pages = {15-25}, publisher = {Elsevier}, abstract = {Objectives: Despite promising research showing that physical activity (PA) might improve cognitive functioning in people with mild cognitive impairment (MCI), people with MCI are less physically active compared with the general population. Therefore, the aim of this study was to assess PA correlates among community-dwelling older people with MCI in six low- and middle-income countries.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Objectives: Despite promising research showing that physical activity (PA) might improve cognitive functioning in people with mild cognitive impairment (MCI), people with MCI are less physically active compared with the general population. Therefore, the aim of this study was to assess PA correlates among community-dwelling older people with MCI in six low- and middle-income countries. |
Tyrovolas, S; Escriva, N G; Ayuso-Mateos, J L; Chatterji, S; Koyanagi, A; Miret, M; Victoria, M; Olaya, B; Tobiasz-Adamczyk, B; Koskinen, S; Leonardi, M; Haro, J M Frailty and health status of older individuals in three European countries: The COURAGE cross-sectional study Artículo de revista Exp. Gerontol., 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29499372, title = {Frailty and health status of older individuals in three European countries: The COURAGE cross-sectional study}, author = {S Tyrovolas and N G Escriva and J L Ayuso-Mateos and S Chatterji and A Koyanagi and M Miret and M Victoria and B Olaya and B Tobiasz-Adamczyk and S Koskinen and M Leonardi and J M Haro}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29499372}, year = {2018}, date = {2018-02-27}, journal = {Exp. Gerontol.}, abstract = {Frailty is characterized by several deficits in multiple health related domains. Although cognition is among the important components of frailty, there is lack of evidence on the role of specific neuro-cognitive dimensions. The primary aim of the present work was to evaluate the multidimensional definition of frailty, and to assess whether neuro-cognitive function is a constituent of the frailty syndrome among adults aged \^{a}‰¥50 years living in three European countries. As a secondary aim, the construct validity of the created frailty index was tested (with inpatient and outpatient hospitalization), as well as its determinants. Data were obtained from a cross-sectional, community-based, nationally-representative survey conducted in Finland, Poland and Spain (n = 7987 individuals aged \^{a}‰¥50 years). Socio-demographic, clinical, lifestyle and social factors were assessed using validated procedures. Cognitive function was assessed with the following tests: learning and short-term memory, working memory and verbal fluency. A frailty index was constructed based on 31 frailty attributes. Principal component analysis was used to identify the components of the frailty index. Logistic and Poisson regression analysis was also conducted. The factor analysis on the components of the index extracted three main dimensions for frailty (disability and daily functioning, cognitive function, chronic health conditions), confirming the multiple dimensions of frailty. Various socio-demographic (e.g., financial status, education level) and lifestyle habits (alcohol consumption) were related with frailty. The presence of frailty was associated with 3.1 times higher odds for inpatient hospitalization (95%CI 2.75 to 3.51). Frailty was also related with higher frequency of outpatient visits. These findings suggest that frailty is a multidimensional concept with three major dimensions. Neuro-congitive function seems to be a separate dimension of the frailty syndrome. Smoking habits and alcohol intake were positively related with frailty while inpatient and outpatient hospitalization were found to be related to level of frailty.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Frailty is characterized by several deficits in multiple health related domains. Although cognition is among the important components of frailty, there is lack of evidence on the role of specific neuro-cognitive dimensions. The primary aim of the present work was to evaluate the multidimensional definition of frailty, and to assess whether neuro-cognitive function is a constituent of the frailty syndrome among adults aged ≥50 years living in three European countries. As a secondary aim, the construct validity of the created frailty index was tested (with inpatient and outpatient hospitalization), as well as its determinants. Data were obtained from a cross-sectional, community-based, nationally-representative survey conducted in Finland, Poland and Spain (n = 7987 individuals aged ≥50 years). Socio-demographic, clinical, lifestyle and social factors were assessed using validated procedures. Cognitive function was assessed with the following tests: learning and short-term memory, working memory and verbal fluency. A frailty index was constructed based on 31 frailty attributes. Principal component analysis was used to identify the components of the frailty index. Logistic and Poisson regression analysis was also conducted. The factor analysis on the components of the index extracted three main dimensions for frailty (disability and daily functioning, cognitive function, chronic health conditions), confirming the multiple dimensions of frailty. Various socio-demographic (e.g., financial status, education level) and lifestyle habits (alcohol consumption) were related with frailty. The presence of frailty was associated with 3.1 times higher odds for inpatient hospitalization (95%CI 2.75 to 3.51). Frailty was also related with higher frequency of outpatient visits. These findings suggest that frailty is a multidimensional concept with three major dimensions. Neuro-congitive function seems to be a separate dimension of the frailty syndrome. Smoking habits and alcohol intake were positively related with frailty while inpatient and outpatient hospitalization were found to be related to level of frailty. |
Koyanagi, A; Lara, E; Stubbs, B; Carvalho, A F; Oh, H; Stickley, A; Veronese, N; Vancampfort, D Chronic Physical Conditions, Multimorbidity, and Mild Cognitive Impairment in Low- and Middle-Income Countries Artículo de revista J Am Geriatr Soc, 66 (4), pp. 721–727, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29427504, title = {Chronic Physical Conditions, Multimorbidity, and Mild Cognitive Impairment in Low- and Middle-Income Countries}, author = {A Koyanagi and E Lara and B Stubbs and A F Carvalho and H Oh and A Stickley and N Veronese and D Vancampfort}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29427504}, year = {2018}, date = {2018-02-10}, journal = {J Am Geriatr Soc}, volume = {66}, number = {4}, pages = {721--727}, abstract = {To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). Nationally representative, cross-sectional, community-based study. Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health. Individuals aged 50 and older (N=32,715; mean age 62.1 \^{A}± 15.6; 51.7% female). The definition of MCI was based on the recommendations of the National Institute on Ageing and Alzheimer's Association. Ten chronic conditions were assessed (angina pectoris, arthritis, asthma, cataract, chronic lung disease, diabetes mellitus, edentulism, hearing problems, hypertension, stroke). Multivariable logistic regression analysis was conducted to assess the association between chronic physical conditions, multimorbidity (\^{a}‰¥2 chronic conditions), and MCI. The prevalence of multimorbidity was 49.8% (95% confidence interval (CI)=48.1-51.5%) and of MCI was 15.3% (95% CI=14.4-16.3%). After adjustment for potential confounders, edentulism (odds ratio (OR)=1.24), arthritis (OR=1.24), chronic lung disease (OR=1.29), cataract (OR=1.33), stroke (OR=1.94), hearing problems (OR=2.27), and multimorbidity (OR=1.40) were significantly associated with MCI. There was a gradual increase in the likelihood of MCI (1 condition: OR=1.21, 95% CI=1.03-1.42; \^{a}‰¥4 conditions: OR=2.07, 95% CI=1.70-2.52). These results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI and whether prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia, especially in LMICs.}, keywords = {}, pubstate = {published}, tppubtype = {article} } To assess the association between chronic physical conditions and multimorbidity and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs). Nationally representative, cross-sectional, community-based study. Six countries that participated in the World Health Organization Study on Global Ageing and Adult Health. Individuals aged 50 and older (N=32,715; mean age 62.1 ± 15.6; 51.7% female). The definition of MCI was based on the recommendations of the National Institute on Ageing and Alzheimer's Association. Ten chronic conditions were assessed (angina pectoris, arthritis, asthma, cataract, chronic lung disease, diabetes mellitus, edentulism, hearing problems, hypertension, stroke). Multivariable logistic regression analysis was conducted to assess the association between chronic physical conditions, multimorbidity (≥2 chronic conditions), and MCI. The prevalence of multimorbidity was 49.8% (95% confidence interval (CI)=48.1-51.5%) and of MCI was 15.3% (95% CI=14.4-16.3%). After adjustment for potential confounders, edentulism (odds ratio (OR)=1.24), arthritis (OR=1.24), chronic lung disease (OR=1.29), cataract (OR=1.33), stroke (OR=1.94), hearing problems (OR=2.27), and multimorbidity (OR=1.40) were significantly associated with MCI. There was a gradual increase in the likelihood of MCI (1 condition: OR=1.21, 95% CI=1.03-1.42; ≥4 conditions: OR=2.07, 95% CI=1.70-2.52). These results highlight the need to investigate the underlying mechanisms linking chronic conditions and MCI and whether prevention or treatment of chronic conditions or multimorbidity can reduce the onset of cognitive decline and subsequent dementia, especially in LMICs. |
Perez-Hernandez, B; Lopez-Garcia, E; Graciani, A; Ayuso-Mateos, J L; Rodriguez-Artalejo, F; Garcia-Esquinas, E Housing conditions and risk of physical function limitations: a prospective study of community-dwelling older adults Artículo de revista J Public Health (Oxf), 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29351629, title = {Housing conditions and risk of physical function limitations: a prospective study of community-dwelling older adults}, author = {B Perez-Hernandez and E Lopez-Garcia and A Graciani and J L Ayuso-Mateos and F Rodriguez-Artalejo and E Garcia-Esquinas}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29351629}, year = {2018}, date = {2018-01-17}, journal = {J Public Health (Oxf)}, abstract = {Poor housing conditions have been associated with an increased risk of morbidity and mortality in old age. Prospective cohort of 1602 older adults followed from 2012 to 2015. Poor conditions were defined as living in a walk-up building, lacking piped hot water or heating, feeling frequently cold at home, lacking a bathtub/shower, a refrigerator, a washing machine, an own room or a landline. Frailty was assessed with the Fried criteria, lower extremities performance with the Short Physical Performance Battery (SPPB), and disability in instrumental activities of daily living (IADL) with the Lawton and Brody questionnaire. During follow-up, 55 individuals (4.2%) developed frailty and 107 (7.2%) IADL disability. Mean (SD) SPPB values at baseline and at follow-up were 8.5 (2.5) and 8.6 (2.4), respectively. After multivariate adjustment, participants who lived in homes with \^{a}‰¥1 poor conditions showed a higher risk of frailty (odds ratio [OR] = 2.02; 95% confidence interval [95% CI]: 1.09-3.75) and transportation disability (OR = 3.50; 95% CI: 1.38-8.88). Lacking heating and feeling frequently cold were associated with an increased risk of exhaustion (OR = 2.34; 95% CI: 1.00-5.48) and transportation disability (OR = 3.31; 95% CI: 1.07-10.2), respectively. Prevention programs targeting functional limitations in older adults should ensure that they live in suitable housing conditions.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Poor housing conditions have been associated with an increased risk of morbidity and mortality in old age. Prospective cohort of 1602 older adults followed from 2012 to 2015. Poor conditions were defined as living in a walk-up building, lacking piped hot water or heating, feeling frequently cold at home, lacking a bathtub/shower, a refrigerator, a washing machine, an own room or a landline. Frailty was assessed with the Fried criteria, lower extremities performance with the Short Physical Performance Battery (SPPB), and disability in instrumental activities of daily living (IADL) with the Lawton and Brody questionnaire. During follow-up, 55 individuals (4.2%) developed frailty and 107 (7.2%) IADL disability. Mean (SD) SPPB values at baseline and at follow-up were 8.5 (2.5) and 8.6 (2.4), respectively. After multivariate adjustment, participants who lived in homes with ≥1 poor conditions showed a higher risk of frailty (odds ratio [OR] = 2.02; 95% confidence interval [95% CI]: 1.09-3.75) and transportation disability (OR = 3.50; 95% CI: 1.38-8.88). Lacking heating and feeling frequently cold were associated with an increased risk of exhaustion (OR = 2.34; 95% CI: 1.00-5.48) and transportation disability (OR = 3.31; 95% CI: 1.07-10.2), respectively. Prevention programs targeting functional limitations in older adults should ensure that they live in suitable housing conditions. |
de la Fuente, J; Caballero, F F; Sanchez-Niubo, A; Panagiotakos, D B; Prina, M A; Arndt, H; Haro, J M; Chatterji, S; Ayuso-Mateos, J L Determinants of health trajectories in England and the US: an approach to identify different patterns of healthy aging Artículo de revista J. Gerontol. A Biol. Sci. Med. Sci., 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29346518, title = {Determinants of health trajectories in England and the US: an approach to identify different patterns of healthy aging}, author = {J de la Fuente and F F Caballero and A Sanchez-Niubo and D B Panagiotakos and M A Prina and H Arndt and J M Haro and S Chatterji and J L Ayuso-Mateos}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29346518}, year = {2018}, date = {2018-01-16}, journal = {J. Gerontol. A Biol. Sci. Med. Sci.}, abstract = {Aging is a multidimensional process with a remarkable inter-individual variability. This study is focused on identifying groups of population with similar aging patterns, and to define the health trajectories of these groups. Socio-demographic and health determinants of these trajectories are also identified. Data from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) were used. A set of self-reported health items and measured tests were used to generate a latent health metric by means of a Bayesian multilevel IRT model, assessing the ability of the metric to predict mortality. Then, a Growth Mixture Model (GMM) was conducted in each study to identify latent classes and assess health trajectories. Kaplan-Meier survival curves were obtained for each class and a multinomial logistic regression was used to identify determinants of these trajectories. The health score generated showed an adequate ability to predict mortality over ten years in ELSA [AUC=0.74; 95% CI=(0.72,0.75)] and HRS [AUC=0.74; 95% CI=(0.73,0.75)]. By means of GMM, four latent classes were identified in ELSA and five in HRS. Chronic conditions, no qualification and low level of household wealth were associated to the classes which showed a higher mortality in both studies. The method based on the creation of a common metric of health and the use of GMM to identify similar patterns of aging, allows for the comparison of trajectories of health across longitudinal surveys. Multimorbidity, educational level and household wealth could be considered as determinants associated to these trajectories.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Aging is a multidimensional process with a remarkable inter-individual variability. This study is focused on identifying groups of population with similar aging patterns, and to define the health trajectories of these groups. Socio-demographic and health determinants of these trajectories are also identified. Data from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS) were used. A set of self-reported health items and measured tests were used to generate a latent health metric by means of a Bayesian multilevel IRT model, assessing the ability of the metric to predict mortality. Then, a Growth Mixture Model (GMM) was conducted in each study to identify latent classes and assess health trajectories. Kaplan-Meier survival curves were obtained for each class and a multinomial logistic regression was used to identify determinants of these trajectories. The health score generated showed an adequate ability to predict mortality over ten years in ELSA [AUC=0.74; 95% CI=(0.72,0.75)] and HRS [AUC=0.74; 95% CI=(0.73,0.75)]. By means of GMM, four latent classes were identified in ELSA and five in HRS. Chronic conditions, no qualification and low level of household wealth were associated to the classes which showed a higher mortality in both studies. The method based on the creation of a common metric of health and the use of GMM to identify similar patterns of aging, allows for the comparison of trajectories of health across longitudinal surveys. Multimorbidity, educational level and household wealth could be considered as determinants associated to these trajectories. |
Domenech-Abella, J; Mundo, J; Moneta, M V; Perales, J; Ayuso-Mateos, J L; Miret, M; Haro, J M; Olaya, B The impact of socioeconomic status on the association between biomedical and psychosocial well-being and all-cause mortality in older Spanish adults Artículo de revista Soc Psychiatry Psychiatr Epidemiol, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29322199, title = {The impact of socioeconomic status on the association between biomedical and psychosocial well-being and all-cause mortality in older Spanish adults}, author = {J Domenech-Abella and J Mundo and M V Moneta and J Perales and J L Ayuso-Mateos and M Miret and J M Haro and B Olaya}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29322199}, year = {2018}, date = {2018-01-01}, journal = {Soc Psychiatry Psychiatr Epidemiol}, abstract = {The aim of this paper was to analyze the effect of biomedical and psychosocial well-being, based on distinct successful aging models (SA), on time to mortality, and determine whether this effect was modified by socioeconomic status (SES) in a nationally representative sample of older Spanish adults. Data were taken from a 3-year follow-up study with 2783 participants aged 50 or over. Vital status was ascertained using national registers or asking participants' relatives. Kaplan-Meier curves were used to estimate the time to death by SES, and levels of biomedical and psychosocial SA. Cox proportional hazard regression models were conducted to explore interactions between SES and SA models while adjusting for gender, age, and marital status. Lower levels of SES and biomedical and psychosocial SA were associated with low probability of survival. Only the interaction between SES and biomedical SA was significant. Biomedical SA impacted on mortality rates among individuals with low SES but not on those with medium or high SES, whereas psychosocial SA affected mortality regardless of SES. Promoting equal access to health care system and improved psychosocial well-being could be a protective factor against premature mortality in older Spanish adults with low SES.}, keywords = {}, pubstate = {published}, tppubtype = {article} } The aim of this paper was to analyze the effect of biomedical and psychosocial well-being, based on distinct successful aging models (SA), on time to mortality, and determine whether this effect was modified by socioeconomic status (SES) in a nationally representative sample of older Spanish adults. Data were taken from a 3-year follow-up study with 2783 participants aged 50 or over. Vital status was ascertained using national registers or asking participants' relatives. Kaplan-Meier curves were used to estimate the time to death by SES, and levels of biomedical and psychosocial SA. Cox proportional hazard regression models were conducted to explore interactions between SES and SA models while adjusting for gender, age, and marital status. Lower levels of SES and biomedical and psychosocial SA were associated with low probability of survival. Only the interaction between SES and biomedical SA was significant. Biomedical SA impacted on mortality rates among individuals with low SES but not on those with medium or high SES, whereas psychosocial SA affected mortality regardless of SES. Promoting equal access to health care system and improved psychosocial well-being could be a protective factor against premature mortality in older Spanish adults with low SES. |
Rico-Uribe, L A; Caballero, F F; Martin-Maria, N; Cabello, M; Ayuso-Mateos, J L; Miret, M Association of loneliness with all-cause mortality: A meta-analysis Artículo de revista PLoS ONE, 13 (1), pp. e0190033, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29300743, title = {Association of loneliness with all-cause mortality: A meta-analysis}, author = {L A Rico-Uribe and F F Caballero and N Martin-Maria and M Cabello and J L Ayuso-Mateos and M Miret}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29300743}, year = {2018}, date = {2018-01-01}, journal = {PLoS ONE}, volume = {13}, number = {1}, pages = {e0190033}, abstract = {Loneliness has social and health implications. The aim of this article is to evaluate the association of loneliness with all-cause mortality. Pubmed, PsycINFO, CINAHL and Scopus databases were searched through June 2016 for published articles that measured loneliness and mortality. The main characteristics and the effect size values of each article were extracted. Moreover, an evaluation of the quality of the articles included was also carried out. A meta-analysis was performed firstly with all the included articles and secondly separating by gender, using a random effects model. A total of 35 articles involving 77220 participants were included in the systematic review. Loneliness is a risk factor for all-cause mortality [pooled HR = 1.22, 95% CI = (1.10, 1.35), p < 0.001] for both genders together, and for women [pooled HR = 1.26, 95% CI = (1.07, 1.48); p = 0.005] and men [pooled HR = 1.44; 95% CI = (1.19, 1.76); p < 0.001] separately. Loneliness shows a harmful effect for all-cause mortality and this effect is slightly stronger in men than in women. Moreover, the impact of loneliness was independent from the quality evaluation of each article and the effect of depression.}, keywords = {}, pubstate = {published}, tppubtype = {article} } Loneliness has social and health implications. The aim of this article is to evaluate the association of loneliness with all-cause mortality. Pubmed, PsycINFO, CINAHL and Scopus databases were searched through June 2016 for published articles that measured loneliness and mortality. The main characteristics and the effect size values of each article were extracted. Moreover, an evaluation of the quality of the articles included was also carried out. A meta-analysis was performed firstly with all the included articles and secondly separating by gender, using a random effects model. A total of 35 articles involving 77220 participants were included in the systematic review. Loneliness is a risk factor for all-cause mortality [pooled HR = 1.22, 95% CI = (1.10, 1.35), p < 0.001] for both genders together, and for women [pooled HR = 1.26, 95% CI = (1.07, 1.48); p = 0.005] and men [pooled HR = 1.44; 95% CI = (1.19, 1.76); p < 0.001] separately. Loneliness shows a harmful effect for all-cause mortality and this effect is slightly stronger in men than in women. Moreover, the impact of loneliness was independent from the quality evaluation of each article and the effect of depression. |
Hegerl, U; Mergl, R; Sander, C; Dietzel, J; Bitter, I; Demyttenaere, K; Gusmao, R; Arrillaga, A G; Zorrilla, I; Alocen, A G; Sola, V P; Vieta, E; Juckel, G; Zimmermann, U S; Bauer, M; Sienaert, P; Quintao, S; Edel, M A; Bolyos, C; Ayuso-Mateos, J L; Lopez-Garcia, P; Kluge, M A multi-centre, randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study) Artículo de revista Eur Neuropsychopharmacol, 28 (1), pp. 185–194, 2018. Resumen | Enlaces | BibTeX | Etiquetas: @article{pmid29174864, title = {A multi-centre, randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study)}, author = {U Hegerl and R Mergl and C Sander and J Dietzel and I Bitter and K Demyttenaere and R Gusmao and A G Arrillaga and I Zorrilla and A G Alocen and V P Sola and E Vieta and G Juckel and U S Zimmermann and M Bauer and P Sienaert and S Quintao and M A Edel and C Bolyos and J L Ayuso-Mateos and P Lopez-Garcia and M Kluge}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29174864}, year = {2018}, date = {2018-01-01}, journal = {Eur Neuropsychopharmacol}, volume = {28}, number = {1}, pages = {185--194}, abstract = {Based on many clinical and preclinical findings the 'vigilance regulation model of mania' postulates that an unstable regulation of wakefulness is a pathogenetic factor in both mania and Attention Deficit Hyperactivity Disorder (ADHD) and induces hyperactivity and sensation seeking as an autoregulatory attempt to stabilize wakefulness. Accordingly, stimulant medications with their vigilance stabilizing properties could have rapid antimanic effects similar to their beneficial effects in ADHD. The MEMAP study - a multi-center, double-blind, placebo-controlled and randomized clinical trial (RCT) - assessed the antimanic efficacy and safety of a 2.5-day treatment with methylphenidate (20-40mg/day). Of 157 screened patients with acute mania, 42 were randomly assigned to receive 20-40mg per day of methylphenidate in one or two applications, or placebo. The primary outcome was the change in Young Mania Rating Scale (YMRS) sum scores from baseline to day 2.5 in the methylphenidate group compared to the placebo group. A group sequential design was chosen to justify early RCT termination based on efficacy or futility at an interim analysis after inclusion of 40 patients. In the interim analysis, the change from baseline in the YMRS total score at day 2.5 was not significantly different between both groups (F(1,37)=0.23; p=0.64). Thus, futility was declared for methylphenidate and the RCT was stopped. In summary, although methylphenidate was well tolerated and safe in the full analysis set, it failed to show efficacy in the treatment of acute mania. clinicaltrials.gov (URL: http://www.clinicaltrials.gov; registration number: NCT01541605).}, keywords = {}, pubstate = {published}, tppubtype = {article} } Based on many clinical and preclinical findings the 'vigilance regulation model of mania' postulates that an unstable regulation of wakefulness is a pathogenetic factor in both mania and Attention Deficit Hyperactivity Disorder (ADHD) and induces hyperactivity and sensation seeking as an autoregulatory attempt to stabilize wakefulness. Accordingly, stimulant medications with their vigilance stabilizing properties could have rapid antimanic effects similar to their beneficial effects in ADHD. The MEMAP study - a multi-center, double-blind, placebo-controlled and randomized clinical trial (RCT) - assessed the antimanic efficacy and safety of a 2.5-day treatment with methylphenidate (20-40mg/day). Of 157 screened patients with acute mania, 42 were randomly assigned to receive 20-40mg per day of methylphenidate in one or two applications, or placebo. The primary outcome was the change in Young Mania Rating Scale (YMRS) sum scores from baseline to day 2.5 in the methylphenidate group compared to the placebo group. A group sequential design was chosen to justify early RCT termination based on efficacy or futility at an interim analysis after inclusion of 40 patients. In the interim analysis, the change from baseline in the YMRS total score at day 2.5 was not significantly different between both groups (F(1,37)=0.23; p=0.64). Thus, futility was declared for methylphenidate and the RCT was stopped. In summary, although methylphenidate was well tolerated and safe in the full analysis set, it failed to show efficacy in the treatment of acute mania. clinicaltrials.gov (URL: http://www.clinicaltrials.gov; registration number: NCT01541605). |
